Document Detail

Antepartum diagnosis of goitrous hypothyroidism by fetal ultrasonography and amniotic fluid thyrotropin concentration.
MedLine Citation:
PMID:  6384258     Owner:  NLM     Status:  MEDLINE    
Ultrasonography of a 26-week-old fetus suggested the presence of a goiter. Amniocentesis was performed at 26 and 38 weeks gestation to evaluate thyroid function. An elevated amniotic fluid TSH level was found on both occasions, though amniotic fluid T4, T3, and rT3 levels were similar to those of euthyroid fetuses. The diagnosis of goitrous hypothyroidism was confirmed at birth. Therapy with thyroid hormone was instituted on the first day of life. Growth and development of the infant have been normal during the first year of his life. We suggest that the measurement of amniotic fluid TSH can be useful in the diagnosis of intrauterine primary hypothyroidism.
I A Kourides; R L Berkowitz; S Pang; F C Van Natta; C M Barone; F Ginsberg-Fellner
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  59     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-11-21     Completed Date:  1984-11-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1016-8     Citation Subset:  AIM; IM    
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MeSH Terms
Amniotic Fluid / analysis*
Goiter / diagnosis*,  metabolism
Hypothyroidism / diagnosis*,  metabolism
Prenatal Diagnosis / methods*
Thyrotropin / isolation & purification*
Grant Support
Reg. No./Substance:

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