Document Detail


Antenatal ultrasound and postnatal autopsy findings in terminations after 12 weeks' gestation due to fetal abnormality: population-based study in Western Norway, 1988-2002.
MedLine Citation:
PMID:  19517278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Ultrasound screening has been part of antenatal care for several decades, and warrants high expertise to meet the criteria for a worthwhile screening program. In particular, the rate of false positives should be low. PURPOSE: To examine time trends of pregnancy terminations for fetal abnormality after 12 weeks' gestation, and to assess the agreement between antenatal ultrasound and post-termination autopsy findings for the main pathologies leading to termination. MATERIAL AND METHODS: During the period 1988 to 2002, 198 pregnancies were terminated for fetal abnormality after 12 weeks' gestation. We reviewed the case notes for those 151 who were autopsied (male/female/undetermined ;= ;91/56/4). Annual rates of live births and stillbirths were retrieved from the Medical Birth Registry of Norway. RESULTS: Antenatal ultrasound provided a correct diagnosis of the major abnormality in 149/151 cases (99%), based on post-termination autopsy findings. The annual rate of terminations after 12 weeks' gestation varied between 0.6 and 3.4 (mean 1.8) per 1000 live births, with a trend toward higher rates over the study period (P=0.001, chi-square test for linear-by-linear association). CONCLUSION: The specificity of antenatal ultrasound for major abnormalities was high, as compared to postnatal autopsy findings. The mean annual rates of termination after 12 weeks' gestation tended to increase over the 14-year study period.
Authors:
A P Parkar; Ø E Olsen; H Maartmann-Moe; A K Daltveit; K Gjelland; K Rosendahl
Related Documents :
21711208 - Recurrent johanson-blizzard syndrome in a triplet pregnancy complicated by urethral obs...
19190928 - A randomized controlled trial comparing powdery sublingual misoprostol and sublingual m...
11574498 - Double-blind randomized trial of mifepristone in combination with vaginal gemeprost or ...
12867908 - Induction of labor: the misoprostol controversy.
8408828 - In utero acute graft-versus-host disease in a neonate with severe combined immunodefici...
9221988 - Sex chromosomal anomalies in pregnancies conceived through intracytoplasmic sperm injec...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  50     ISSN:  1600-0455     ISO Abbreviation:  -     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-24     Completed Date:  2009-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  816-22     Citation Subset:  IM    
Affiliation:
Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Induced
Autopsy
Chi-Square Distribution
Congenital Abnormalities / epidemiology,  ultrasonography*
Female
Humans
Infant, Newborn
Male
Norway / epidemiology
Pregnancy
Pregnancy Trimester, First
Registries
Retrospective Studies
Sensitivity and Specificity
Stillbirth / epidemiology
Ultrasonography, Prenatal*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Systemic detection of doxycycline after local administration.
Next Document:  Procedural and declarative memory in children with and without specific language impairment.