Document Detail

Antenatal screening for Down's syndrome in assisted reproductive pregnancies.
MedLine Citation:
PMID:  10582790     Owner:  NLM     Status:  MEDLINE    
The wide use of assisted conception methods has risen dramatically. The greater proportion of singletons, twins and high order of multiplicity conceived by those methods have already focused the medical community to various obstetric complications. Recently, there have been suggestions that the levels of mid-gestation serum markers, particularly human chorionic gonadotrophin (HCG), might be affected by assisted conception, leading to higher false-positive results. Furthermore, women who conceived after assisted reproduction methods are on average older, and in many cases their current pregnancy was achieved after long-standing infertility and might even be their last one. This is why they are extremely wary of any invasive fetal karyotyping. Therefore, every effort should be made to provide them with the most accurate screening of Down's syndrome (DS) risk. In this respect, nuchal translucency (NT) measurement, which has been reported to be another effective screening method, might be a more reliable marker in these pregnancies. This review explores the problematic issue of antenatal DS screening in assisted conception pregnancies. For the singletons and twins, a sequential NT and second-trimester serum marker screening can be offered, thus producing a single risk estimation which seems to be more accurate. For the high order of multiplicity, the NT offers additional important data, which can be taken in consideration both as a screening tool for DS and if fetal reduction is planned.
R Maymon; E Dreazen; Z Weinraub; I Bukovsky; A Herman
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Human reproduction update     Volume:  5     ISSN:  1355-4786     ISO Abbreviation:  Hum. Reprod. Update     Publication Date:    1999 Sep-Oct
Date Detail:
Created Date:  1999-12-30     Completed Date:  1999-12-30     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9507614     Medline TA:  Hum Reprod Update     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  530-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Assaf Harofe Medical Centre, Zerifin, Israel.
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MeSH Terms
Biological Markers
Chorionic Gonadotropin / blood
Diseases in Twins / diagnosis
Down Syndrome / diagnosis*,  embryology,  prevention & control
Estriol / blood
False Positive Reactions
Maternal Age
Pregnancy Trimesters
Pregnancy, Multiple / blood*
Prenatal Diagnosis* / methods
Reproductive Techniques* / adverse effects
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin; 0/alpha-Fetoproteins; 50-27-1/Estriol

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