Document Detail


Antenatal phenobarbital and bilirubin metabolism in the very low birth weight infant.
MedLine Citation:
PMID:  3207127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prior studies in term infants have suggested that in utero phenobarbital exposure may accelerate bilirubin metabolism by stimulating hepatocyte glucuronyl transferase activity. This report reviews our experience with maternal phenobarbital therapy and fetal bilirubin conjugation in the very premature fetus. Mothers with arrested premature labor between 26 and 33 weeks' gestation were randomly assigned to receive oral phenobarbital (90 mg daily) or not. Infants in the two groups were similar in race, birth weight, and gestational age. Conjugated bilirubin levels at birth were significantly higher for infants receiving several days of phenobarbital in utero than no therapy (0.31 +/- 0.03 vs 0.16 +/- 0.01 mg dl, p less than 0.01). A smaller portion of infants exposed to phenobarbital in utero required phototherapy (10/23, 43% vs 24/29, 83%, p less than 0.01), which was also more likely to be delayed beyond 48 hours after delivery. Antenatal phenobarbital enhances bilirubin conjugation before delivery of a very low birth weight infant.
Authors:
W Rayburn; S Donn; E Piehl; A Compton
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  159     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-31     Completed Date:  1989-01-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1491-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor.
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MeSH Terms
Descriptor/Qualifier:
Bilirubin / blood*,  metabolism
Delivery, Obstetric
Female
Humans
Hyperbilirubinemia / drug therapy
Infant, Low Birth Weight / blood*,  metabolism
Infant, Newborn
Phenobarbital / therapeutic use*
Phototherapy
Pregnancy
Prenatal Care*
Time Factors
Chemical
Reg. No./Substance:
50-06-6/Phenobarbital; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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