Document Detail

Antenatal management and outcomes of gastroschisis in the U.K.
MedLine Citation:
PMID:  23135874     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The birth prevalence of gastroschisis is increasing worldwide, yet little evidence exists concerning the optimal monitoring strategies after diagnosis. The aim of this study was to describe the U.K. prevalence, antenatal management and outcomes of affected pregnancies.
METHODS: Cases were identified throughout the U.K. between October 2006 and September 2007, using three different sources.
RESULTS: The overall birth prevalence of gastroschisis was 4.2 cases per 10, 000 total births (95% CI 3.6-4.8). Infants were variably monitored with growth scans (90%), umbilical artery Doppler ultrasound (85%), cardiotocography (65%) and biophysical profile (27%). Bowel measurements were undertaken for only 113 infants (52%). Eighty-nine women (43%) were induced and 63 (31%) laboured spontaneously. Eleven women (5%) had an elective caesarean delivery where the sole indication was fetal gastroschisis.
CONCLUSIONS: The variability in management and paucity of evidence on antenatal monitoring approaches suggests there may be a place for randomised trials of fetal surveillance strategies in order to develop the evidence to improve outcomes for the at-risk fetus with gastroschisis. This study suggests that case ascertainment by regional congenital anomaly registers is high; extension of the coverage of these registers to the entire cohort of U.K. births would facilitate ongoing surveillance and research.
Timothy G Overton; Matthias R Pierce; Haiyan Gao; Jennifer J Kurinczuk; Patsy Spark; Elizabeth S Draper; Sean Marven; Peter Brocklehurst; Marian Knight
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-08
Journal Detail:
Title:  Prenatal diagnosis     Volume:  32     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-24     Revised Date:  2014-03-14    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  1256-62     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons, Ltd.
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MeSH Terms
Cardiotocography / statistics & numerical data
Delivery, Obstetric / statistics & numerical data
Gastroschisis / diagnosis,  mortality*
Great Britain / epidemiology
Ultrasonography, Prenatal / statistics & numerical data
Young Adult
Grant Support
PDA/02/06/044//Department of Health; //Department of Health

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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