Document Detail


Antenatal interventions for preventing the transmission of cytomegalovirus (CMV) from the mother to fetus during pregnancy and adverse outcomes in the congenitally infected infant.
MedLine Citation:
PMID:  21412919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cytomegalovirus (CMV) is a herpesvirus and the most common cause of congenital infection in developed countries. Congenital CMV infection can have devastating consequences to the fetus. The high incidence and the serious morbidity associated with congenital CMV infection emphasise the need for effective interventions to prevent the antenatal transmission of CMV infection.
OBJECTIVES: The aim of this review was to assess the benefits and harms of interventions used during pregnancy to prevent mother to fetus transmission of CMV infection.
SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 December 2010).
SELECTION CRITERIA: All randomised controlled trials (RCTs) and quasi RCTs investigating antenatal interventions for preventing the transmission of CMV from the mother to fetus during pregnancy and adverse outcomes in the congenitally infected infant.
DATA COLLECTION AND ANALYSIS: Two review authors independently assessed studies for inclusion.
MAIN RESULTS: We identified six studies from the search. None of these studies met the pre-defined criteria for inclusion in this review.
AUTHORS' CONCLUSIONS: To date, no RCTs are available that examine antenatal interventions for preventing the transmission of CMV from the infected mother to fetus during pregnancy and adverse outcomes in the congenitally infected infant. Further research is needed to assess the efficacy of interventions aimed at preventing the transmission of CMV from the mother to fetus during pregnancy including a long-term follow-up of exposed infants and a cost effective analysis.
Authors:
Fergus P McCarthy; Michelle L Giles; Shelley Rowlands; Kara J Purcell; Cheryl A Jones
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-03-16
Journal Detail:
Title:  The Cochrane database of systematic reviews     Volume:  -     ISSN:  1469-493X     ISO Abbreviation:  Cochrane Database Syst Rev     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-17     Completed Date:  2011-04-01     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  100909747     Medline TA:  Cochrane Database Syst Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  CD008371     Citation Subset:  IM    
Affiliation:
Anu Research Centre, Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland.
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MeSH Terms
Descriptor/Qualifier:
Cytomegalovirus Infections / congenital,  transmission*
Female
Fetal Diseases / prevention & control*
Humans
Infectious Disease Transmission, Vertical / prevention & control*
Pregnancy
Pregnancy Complications, Infectious / virology*
Prenatal Care

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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