Document Detail

Antenatal hydronephrosis and the risk of pyelonephritis hospitalization during the first year of life.
MedLine Citation:
PMID:  17482945     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess the risk of hospitalization for pyelonephritis within the first year of life among infants with and without antenatal hydronephrosis. METHODS: A retrospective cohort analysis was performed using linked birth-hospital discharge records from Washington State for 1987 to 2002 to evaluate the risk of hospitalization in the first year of life for pyelonephritis among infants with and without hydronephrosis. Eligible infants had mothers who had prenatal ultrasound screening. A total of 522 singleton infants with antenatal hydronephrosis (International Classification of Diseases, Ninth Revision code 753.2) at the birth hospitalization were identified. For comparison, 2610 singletons without hydronephrosis were selected. We screened hospital discharge records for 1 year after delivery to identify hospitalizations for pyelonephritis and estimate the relative risk (RR) among infants with and without hydronephrosis. RESULTS: Five percent of infants with antenatal hydronephrosis and 1% of those without had pyelonephritis-related hospitalizations in their first year (RR 11.8, 95% confidence interval [CI] 6.8 to 20.5). Among girls the RR was 36.3 (95% CI 10.6 to 124.0); among boys it was 5.3 (95% CI 2.2 to 13.1). In infants with hydronephrosis, girls were more likely to be hospitalized with pyelonephritis (odds ratio 2.9, 95% CI 1.2 to 6.9). CONCLUSIONS: Infants with antenatal hydronephrosis are nearly 12 times more likely to have pyelonephritis-related hospitalizations in the first year of life. This association is stronger in girls. Parents and healthcare providers of infants with this diagnosis should be vigilant for the signs and symptoms of urinary tract infections.
Thomas J Walsh; Stephanie Hsieh; Richard Grady; Beth A Mueller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Urology     Volume:  69     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-07     Completed Date:  2007-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  970-4     Citation Subset:  IM    
Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA.
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MeSH Terms
Age Factors
Case-Control Studies
Child, Preschool
Confidence Intervals
Follow-Up Studies
Hospitalization / statistics & numerical data*
Hydronephrosis / complications*,  diagnosis*
Infant, Newborn
Maternal Age
Odds Ratio
Pyelonephritis / diagnosis,  epidemiology*,  therapy
Reference Values
Retrospective Studies
Risk Assessment
Ultrasonography, Prenatal*
Urinary Tract Infections / diagnosis,  epidemiology*,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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