Document Detail


Antenatal glucocorticoids and the developing brain: mechanisms of action.
MedLine Citation:
PMID:  11972432     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glucocorticoids are critical for normal brain development. There is no doubt that prenatal treatment with synthetic glucocorticoid affords great benefit to the preterm infant. However, animal studies, now carried out in many species, indicate that there may be some long-term physiological costs of early exposure to excess glucocorticoid, and that these appear sex-dependent. Further, the effects may not become apparent until later life. Given the dynamics of corticosteroid receptor systems in late gestation, it is likely that there are critical windows of development when specific regions of the brain are more sensitive to the influence of synthetic glucocorticoid. Once such windows have been identified it will be possible to target prenatal treatments, so as to maximize benefit and reduce risk of long-term effects. Notwithstanding, the data reviewed below indicate that caution should be exercised in the use of multiple course glucocorticoid therapy during pregnancy.
Authors:
S G Matthews
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in neonatology : SN     Volume:  6     ISSN:  1084-2756     ISO Abbreviation:  Semin Neonatol     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2002-04-25     Completed Date:  2002-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9606001     Medline TA:  Semin Neonatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  309-17     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ltd.
Affiliation:
Department of Physiology, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario, Canada. stephen.matthew@utoronto.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Behavior / drug effects
Brain / drug effects,  embryology*
Female
Glucocorticoids / adverse effects,  pharmacology*
Humans
Infant, Newborn
Infant, Premature
Pregnancy
Prenatal Care
Respiratory Distress Syndrome, Newborn / prevention & control
Chemical
Reg. No./Substance:
0/Glucocorticoids

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