Document Detail

Antenatal glucocorticoid therapy for the prevention of respiratory distress syndrome in the premature infant.
MedLine Citation:
PMID:  327364     Owner:  NLM     Status:  MEDLINE    
A double-blind study was designed to investigate the effects of antenatal glucocorticoids on the incidence of respiratory distress syndrome (RDS) in 128 premature human infants. There was a significant reduction (P less than 0.05) in the incidence of RDS in the betamethasone-treated infants to 8.7% compared to an incidence of 22.6% in the saline-treated controls and 25.0% in infants whose mothers received methylprednisolone. The effectiveness of betamethasone in reducing RDS was limited to premature infants delivered to mothers with intact fetal membranes and with an initial L/S ratio less than 2.0. The time between administration of the glucocorticoid and delivery did not significantly affect the incidence of RDS in this study. The failure of methylprednisolone to reduce the development of RDS in premature infants suggests its potential use in maternal therapy during pregnancy with minimal effects on fetal maturation.
M F Block; O R Kling; W M Crosby
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  50     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-09-02     Completed Date:  1977-09-02     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  186-90     Citation Subset:  AIM; IM    
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MeSH Terms
Amniotic Fluid / metabolism
Betamethasone / administration & dosage,  therapeutic use
Clinical Trials as Topic
Double-Blind Method
Fetal Death / epidemiology
Glucocorticoids / therapeutic use*
Infant Mortality
Infant, Newborn
Injections, Intramuscular
Lung / embryology
Maternal-Fetal Exchange
Methylprednisolone / administration & dosage,  therapeutic use
Phosphatidylcholines / metabolism
Prenatal Care*
Respiratory Distress Syndrome, Newborn / epidemiology,  prevention & control*
Sodium Chloride / administration & dosage,  therapeutic use
Sphingomyelins / metabolism
Time Factors
Reg. No./Substance:
0/Glucocorticoids; 0/Phosphatidylcholines; 0/Sphingomyelins; 378-44-9/Betamethasone; 7647-14-5/Sodium Chloride; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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