| Antenatal factors and the development of bronchopulmonary dysplasia. | |
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MedLine Citation:
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PMID: 12667826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The lung of the preterm fetus is often exposed to antenatal glucocorticoids, and histologic chorioamnionitis is frequent. Clinically and experimentally, antenatal glucocorticoids and/or chorioamnionitis are associated with early lung maturation, but in experimental models, both glucocorticoids and intra-uterine inflammation decrease alveolarization. Experimental chorioamnionitis also can amplify the inflammatory response of the preterm lung to mechanical ventilation. In this article, the hypothesis developed is that bronchopulmonary dysplasia occurs because of repetitive adverse lung exposures, or hits, and that the initial hits may be antenatal glucocorticoid exposure and/or antenatal inflammation. |
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Authors:
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Alan H Jobe |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Seminars in neonatology : SN Volume: 8 ISSN: 1084-2756 ISO Abbreviation: Semin Neonatol Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-04-01 Completed Date: 2003-07-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9606001 Medline TA: Semin Neonatol Country: England |
Other Details:
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Languages: eng Pagination: 9-17 Citation Subset: IM |
Affiliation:
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Division of Pulmonary Biology, Cincinnati Children's Hospital, 3333 Burnet Avenue, 45229-3039, Cincinnati,OH, USA. alan.jobe@chmcc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchopulmonary Dysplasia / etiology* Chorioamnionitis / complications*, immunology, physiopathology Female Glucocorticoids / adverse effects* Humans Infant, Newborn Infant, Premature* Lung / drug effects, embryology Pregnancy Pregnancy Complications, Infectious / immunology, physiopathology Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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HD-12714/HD/NICHD NIH HHS; HL-65397/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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