Document Detail


Antenatal factors and the development of bronchopulmonary dysplasia.
MedLine Citation:
PMID:  12667826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lung of the preterm fetus is often exposed to antenatal glucocorticoids, and histologic chorioamnionitis is frequent. Clinically and experimentally, antenatal glucocorticoids and/or chorioamnionitis are associated with early lung maturation, but in experimental models, both glucocorticoids and intra-uterine inflammation decrease alveolarization. Experimental chorioamnionitis also can amplify the inflammatory response of the preterm lung to mechanical ventilation. In this article, the hypothesis developed is that bronchopulmonary dysplasia occurs because of repetitive adverse lung exposures, or hits, and that the initial hits may be antenatal glucocorticoid exposure and/or antenatal inflammation.
Authors:
Alan H Jobe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Seminars in neonatology : SN     Volume:  8     ISSN:  1084-2756     ISO Abbreviation:  Semin Neonatol     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-04-01     Completed Date:  2003-07-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9606001     Medline TA:  Semin Neonatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  9-17     Citation Subset:  IM    
Affiliation:
Division of Pulmonary Biology, Cincinnati Children's Hospital, 3333 Burnet Avenue, 45229-3039, Cincinnati,OH, USA. alan.jobe@chmcc.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Bronchopulmonary Dysplasia / etiology*
Chorioamnionitis / complications*,  immunology,  physiopathology
Female
Glucocorticoids / adverse effects*
Humans
Infant, Newborn
Infant, Premature*
Lung / drug effects,  embryology
Pregnancy
Pregnancy Complications, Infectious / immunology,  physiopathology
Risk Factors
Grant Support
ID/Acronym/Agency:
HD-12714/HD/NICHD NIH HHS; HL-65397/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Glucocorticoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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