Document Detail

Antenatal exposure to doxylamine succinate and dicyclomine hydrochloride (Benedectin) in relation to congenital malformations, perinatal mortality rate, birth weight, and intelligence quotient score.
MedLine Citation:
PMID:  879205     Owner:  NLM     Status:  MEDLINE    
In a prospective cohort study of 20, 282 gravidas and their offspring, congenital malformation rates were similar in the children of over 1,000 women exposed and those not exposed to two components of Bendectin (doxylamine succinate and dicyclomine hydrochloride) during the first four lunar months of pregnancy. In a cohort reduced to 41,337 mother-child pairs for technical reasons, mean birth weight and perinatal mortality rates were similar according to exposure or nonexposure to either drug, as were intelligence quotient scores measured at four years of age in 28,358 of the children. Control of potential confounding factors with a variety of multivariate techniques did not materially alter these findings.
The effects of doxylamine succinate (DAS) and dicylomin hydrochloride (DHC), each of which is contained in the drug Bendectin, administration during pregnancy on offspring was investigated in a prospective cohort study of 50,282 women and their offspring. The overall malformaton rate was similar among 509 heavily exposed infants, 660 moderately exposed children, and 49,113 who were not exposed.Treatment also did not appear to affect mean birth weight, the rate of perinatal mortality, and intelligence quotient scores determined at 4-years of age.
S Shapiro; O P Heinonen; V Siskind; D W Kaufman; R R Monson; D Slone
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  128     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-08-12     Completed Date:  1977-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  480-5     Citation Subset:  AIM; IM; J    
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MeSH Terms
Abnormalities, Drug-Induced*
Birth Weight / drug effects*
Cyclohexanecarboxylic Acids / adverse effects*
Dicyclomine / adverse effects*
Doxylamine / adverse effects*
Environmental Exposure
Infant Mortality*
Infant, Newborn
Intelligence / drug effects*
Maternal-Fetal Exchange*
Pyridines / adverse effects*
Retrospective Studies
United States
Reg. No./Substance:
0/Cyclohexanecarboxylic Acids; 0/Pyridines; 469-21-6/Doxylamine; 77-19-0/Dicyclomine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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