Document Detail


Antenatal dexamethasone therapy does not affect circulating concentrations of insulin-like growth factor binding protein-1.
MedLine Citation:
PMID:  9688419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In animals, dexamethasone administration during pregnancy leads to fetal growth restriction due to enhanced expression of insulin-like growth factor binding protein-1 (IGFBP-1). In humans, there is also a significant inverse correlation between maternal and fetal concentrations of IGFBP-1 and birth weight. During pregnancy, maternal IGFBP-1 is derived from the decidualized endometrium. We have studied the effect of dexamethasone on circulating concentrations of IGFBP-1 in 12 pregnant women who received dexamethasone therapy for fetal lung maturation in anticipation of premature delivery before 34 completed weeks of gestation. Blood samples were collected before dexamethasone administration, at 24 h and 48 h after the course of dexamethasone, and within 24 h of delivery, for the measurement of IGFBP-1. There was no significant change in plasma IGFBP-1 concentrations at 24 and 48 h following dexamethasone therapy, and at delivery (P = 0.666, 0.307 and 0.398, respectively). Therefore, antenatal dexamethasone therapy does not influence decidual synthesis of IGFBP-1.
Authors:
O Ogueh; F A Hills; T Chard; M R Johnson
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  13     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-11-12     Completed Date:  1998-11-12     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1714-6     Citation Subset:  IM    
Affiliation:
Section of Obstetrics and Gynaecology, Imperial College School of Medicine at Chelsea and Westminster Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Dexamethasone / pharmacology*
Embryonic and Fetal Development / drug effects
Female
Fetus / physiology*
Glucocorticoids / pharmacology*
Humans
Insulin-Like Growth Factor Binding Protein 1 / blood*
Lung / drug effects,  embryology
Obstetric Labor, Premature*
Pregnancy / blood*
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Insulin-Like Growth Factor Binding Protein 1; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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