| Antenatal dexamethasone therapy does not affect circulating concentrations of insulin-like growth factor binding protein-1. | |
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MedLine Citation:
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PMID: 9688419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In animals, dexamethasone administration during pregnancy leads to fetal growth restriction due to enhanced expression of insulin-like growth factor binding protein-1 (IGFBP-1). In humans, there is also a significant inverse correlation between maternal and fetal concentrations of IGFBP-1 and birth weight. During pregnancy, maternal IGFBP-1 is derived from the decidualized endometrium. We have studied the effect of dexamethasone on circulating concentrations of IGFBP-1 in 12 pregnant women who received dexamethasone therapy for fetal lung maturation in anticipation of premature delivery before 34 completed weeks of gestation. Blood samples were collected before dexamethasone administration, at 24 h and 48 h after the course of dexamethasone, and within 24 h of delivery, for the measurement of IGFBP-1. There was no significant change in plasma IGFBP-1 concentrations at 24 and 48 h following dexamethasone therapy, and at delivery (P = 0.666, 0.307 and 0.398, respectively). Therefore, antenatal dexamethasone therapy does not influence decidual synthesis of IGFBP-1. |
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Authors:
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O Ogueh; F A Hills; T Chard; M R Johnson |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 13 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-11-12 Completed Date: 1998-11-12 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1714-6 Citation Subset: IM |
Affiliation:
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Section of Obstetrics and Gynaecology, Imperial College School of Medicine at Chelsea and Westminster Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Dexamethasone / pharmacology* Embryonic and Fetal Development / drug effects Female Fetus / physiology* Glucocorticoids / pharmacology* Humans Insulin-Like Growth Factor Binding Protein 1 / blood* Lung / drug effects, embryology Obstetric Labor, Premature* Pregnancy / blood* |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Insulin-Like Growth Factor Binding Protein 1; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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