Document Detail

Antenatal dexamethasone and renal vascular resistance in preterm infants.
MedLine Citation:
PMID:  17444834     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare vascular resistance, renal volume and insulin levels in preterm infants with and without antenatal steroids. METHODS: We studied 61 preterm infants (37 with (group A) and 24 without antecedent of antenatal steroids (group B)). We measured insulin levels at birth in cord blood samples. Ultrasound measurements to evaluate renal arteries resistance index and renal volume were performed during the first 72 h of birth. RESULTS: Preterm infants from group A tended to have lower weight and gestational age than those from group B. Resistance index in renal arteries was lower in preterm infants with steroid therapy compared with group B (right renal artery 0.73 vs. 0.80; P=0.001, and left renal artery 0.75 vs. 0.79; P=0.01, respectively). Renal volume and insulin levels were not different between the groups. In the multiple regression analysis for factors associated with resistance index of renal arteries, only antenatal steroids use was included in the model (R2=0.13; P=0.003 and R2=0.10; P=0.01 for left and right renal arteries, respectively). CONCLUSION: Antenatal dexamethasone in preterm infants during the first 72 h of birth seems to decrease resistance index in renal arteries without affecting renal volume and insulin levels.
Norma Amador-Licona; Juan Manuel Guízar-Mendoza; Jesús Alejandro Maciel-Miranda; Gustavo Romero-Gutiérrez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  43     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-07-19     Revised Date:  2007-09-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  303-6     Citation Subset:  IM    
Unidad de Investigación Epidemiológica, UMAE 48 Bajío, Mexico.
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MeSH Terms
Dexamethasone / pharmacology,  therapeutic use*
Glucocorticoids / pharmacology,  therapeutic use*
Infant, Newborn
Infant, Premature*
Insulin / analysis
Kidney / blood supply*
Prenatal Care
Renal Artery / physiopathology*,  ultrasonography
Vascular Resistance / drug effects*
Reg. No./Substance:
0/Glucocorticoids; 11061-68-0/Insulin; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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