Document Detail

Antenatal and delivery risk factors simultaneously associated with neonatal death and cerebral palsy in preterm infants.
MedLine Citation:
PMID:  9131309     Owner:  NLM     Status:  MEDLINE    
To evaluate the simultaneous effects of antenatal and delivery risk factors on neonatal death and cerebral palsy in preterm infants, we conducted a cohort study of 363 singleton pregnancies delivered between 24 and 33 weeks gestation. Neurodevelopmental outcome of the infants was evaluated at 2 years of corrected age. Risk factors associated with death or cerebral palsy were analysed by politomous logistic regression. Overall, the mortality rate was 14.6% (53/363) and the prevalence of cerebral palsy among surviving infants was 12.3% (38/310). Decreasing gestation and meconium-stained amniotic fluid were the only antenatal factors associated with increased odds for both death and cerebral palsy. The effect magnitude and the predictive value of gestational age were greater for death than for cerebral palsy. After adjustment for confounders, prolonged (> or = 48 h) rupture of membranes (odds ratio 2.98, 95% confidence interval 1.12-7.96) and male sex of the infant (odds ratio 3.01, 95% confidence interval 1.32-6.71) were significantly associated only with cerebral palsy. We conclude that neonatal death and cerebral palsy share few common antenatal risk factors. The characteristics of antenatal risk factors for cerebral palsy suggest that bacterial infestation of the amniotic cavity may be implicated in the etiology of the cerebral impairment.
A Spinillo; E Capuzzo; S Orcesi; M Stronati; M Di Mario; E Fazzi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Early human development     Volume:  48     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-26     Completed Date:  1997-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  81-91     Citation Subset:  IM    
Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo, Pavia, Italy.
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MeSH Terms
Birth Weight
Cerebral Palsy*
Delivery, Obstetric*
Fetal Death*
Gestational Age
Infant, Newborn
Infant, Premature*
Logistic Models
Odds Ratio
Prospective Studies
Risk Factors
Sex Characteristics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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