| Antenatal and delivery risk factors simultaneously associated with neonatal death and cerebral palsy in preterm infants. | |
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MedLine Citation:
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PMID: 9131309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the simultaneous effects of antenatal and delivery risk factors on neonatal death and cerebral palsy in preterm infants, we conducted a cohort study of 363 singleton pregnancies delivered between 24 and 33 weeks gestation. Neurodevelopmental outcome of the infants was evaluated at 2 years of corrected age. Risk factors associated with death or cerebral palsy were analysed by politomous logistic regression. Overall, the mortality rate was 14.6% (53/363) and the prevalence of cerebral palsy among surviving infants was 12.3% (38/310). Decreasing gestation and meconium-stained amniotic fluid were the only antenatal factors associated with increased odds for both death and cerebral palsy. The effect magnitude and the predictive value of gestational age were greater for death than for cerebral palsy. After adjustment for confounders, prolonged (> or = 48 h) rupture of membranes (odds ratio 2.98, 95% confidence interval 1.12-7.96) and male sex of the infant (odds ratio 3.01, 95% confidence interval 1.32-6.71) were significantly associated only with cerebral palsy. We conclude that neonatal death and cerebral palsy share few common antenatal risk factors. The characteristics of antenatal risk factors for cerebral palsy suggest that bacterial infestation of the amniotic cavity may be implicated in the etiology of the cerebral impairment. |
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Authors:
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A Spinillo; E Capuzzo; S Orcesi; M Stronati; M Di Mario; E Fazzi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Early human development Volume: 48 ISSN: 0378-3782 ISO Abbreviation: Early Hum. Dev. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-06-26 Completed Date: 1997-06-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: IRELAND |
Other Details:
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Languages: eng Pagination: 81-91 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, IRCCS Policlinico San Matteo, Pavia, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight Cerebral Palsy* Delivery, Obstetric* Female Fetal Death* Gestational Age Humans Infant, Newborn Infant, Premature* Logistic Models Male Odds Ratio Pregnancy Prospective Studies Risk Factors Sex Characteristics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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