Document Detail

Antenatal corticosteroids in pregnancies complicated by preterm premature rupture of membranes.
MedLine Citation:
PMID:  9351778     Owner:  NLM     Status:  MEDLINE    
In 1994, the National Institutes of Health Consensus Development Conference on Antenatal Steroids recommended corticosteroids between 24 and 30-32 weeks' gestation in pregnancies complicated by preterm premature rupture of membranes (PROM). Since the Consensus Conference, the use of antenatal corticosteroids has increased to approximately 60% of potential treatment candidates. Some of the remaining 40% of pregnant candidates may go untreated because of concern that corticosteroids could increase the risk of neonatal infection. Using decision-analysis techniques, we compared the potential benefit of antenatal corticosteroids in reducing the incidence of severe intraventricular hemorrhage with the potential risk of increasing the rate of neonatal sepsis. Our analysis indicates that the benefit of a small decrease in severe intraventricular hemorrhage outweighs the potential harm of a large increase in the rate of neonatal sepsis. Therefore, we support the Consensus Conference panel's recommendation that antenatal corticosteroids be used in pregnancies complicated by preterm PROM.
M O Gardner; L A Papile; L L Wright
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  90     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-11-21     Completed Date:  1997-11-21     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  851-3     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology and Pediatrics, University of New Mexico School of Medicine, Albuquerque 87131-5286, USA.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use*
Cerebral Hemorrhage / epidemiology,  prevention & control
Consensus Development Conferences, NIH as Topic
Decision Support Techniques
Fetal Membranes, Premature Rupture* / complications,  drug therapy
Infant, Newborn
Infant, Premature, Diseases / chemically induced,  epidemiology,  prevention & control*
Risk Factors
Sepsis / chemically induced,  epidemiology
United States
Reg. No./Substance:
0/Adrenal Cortex Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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