Document Detail


Antenatal corticosteroids: the good, the bad and the unknown.
MedLine Citation:
PMID:  12441700     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: The purpose of this review was to summarize recently published clinical and animal-based studies of antenatal corticosteroids, describe current recommendations for practice, and suggest priority areas for future research. RECENT FINDINGS: A single course of antenatal corticosteroids is known to improve newborn lung function after preterm birth and to reduce the risk of newborn death. Current evidence from animal and clinical studies suggests that additional numbers of courses do not further improve lung function and are associated with risks of adverse consequences. These risks principally include restricted intrauterine growth, altered brain development, postnatal insulin resistance and changes to the hypothalamic-pituitary-adrenal axis. SUMMARY: The research challenges in this field are now centred on uncovering the mechanisms by which cortisol is involved in programming the fetus for its future metabolic life, and discovering ways in which the effectiveness and safety of antenatal glucocorticoids can be enhanced.
Authors:
John P Newnham; Timothy J M Moss; Ilias Nitsos; Deborah M Sloboda
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  14     ISSN:  1040-872X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-20     Completed Date:  2003-04-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  607-12     Citation Subset:  IM    
Affiliation:
The School of Women's Health and Infants' Health, The University of Western Australia, King Edward Memorial Hospital, Perth, Western Australia, Australia. jnewnham@obsgyn.uwa.edu.au
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MeSH Terms
Descriptor/Qualifier:
Cerebral Hemorrhage / prevention & control
Embryonic and Fetal Development / drug effects
Female
Fetal Diseases / chemically induced
Glucocorticoids / administration & dosage*,  adverse effects*
Humans
Infant, Newborn
Obstetric Labor, Premature / prevention & control
Pregnancy
Respiratory Distress Syndrome, Newborn / prevention & control
Grant Support
ID/Acronym/Agency:
HL65397/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Glucocorticoids

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