| Antenatal corticosteroid therapy: short-term effects on fetal behaviour and haemodynamics. | |
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MedLine Citation:
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PMID: 19059817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antenatal corticosteroid therapy to enhance fetal lung maturity in threatened preterm delivery has a number of non-pulmonary side-effects, both beneficial and undesirable. This review focuses on the short-term (transient) effects of betamethasone and dexamethasone on aspects of fetal circulation and behaviour which are used clinically as markers of fetal well-being. We summarise the effects observed, discuss the proposed underlying mechanisms, and emphasise the consequences for clinical decision-making. Recommendations are given to optimise medical care and to minimise the risk of unwarranted iatrogenic preterm delivery. |
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Authors:
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E J H Mulder; R de Heus; G H A Visser |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-12-06 |
Journal Detail:
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Title: Seminars in fetal & neonatal medicine Volume: 14 ISSN: 1744-165X ISO Abbreviation: - Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-03-30 Completed Date: 2009-06-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101240003 Medline TA: Semin Fetal Neonatal Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 151-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands. emulder@umcutrecht.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Betamethasone
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therapeutic use* Dexamethasone / therapeutic use* Female Fetal Movement / drug effects Fetus / blood supply, drug effects* Glucocorticoids / therapeutic use* Heart Rate / drug effects Humans Hypothalamo-Hypophyseal System / drug effects Pituitary-Adrenal System / drug effects Placental Circulation / drug effects Pregnancy Premature Birth Prenatal Care* Ultrasonography, Prenatal |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 378-44-9/Betamethasone; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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