| Antenatal corticosteroid therapy and risk of osteoporosis. | |
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MedLine Citation:
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PMID: 9637126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the risk of maternal osteoporosis associated with antenatal corticosteroid administration for neonatal respiratory distress syndrome prophylaxis. DESIGN: Prospective longitudinal study. SETTING: Maternity unit of Chelsea and Westminster Hospital, London. POPULATION: Fourteen pregnant women who received dexamethasone therapy for fetal lung maturation in anticipation of delivery before 34 completed weeks of gestation. METHODS: Blood samples were collected before dexamethasone administration, 24 hours and 48 hours after the course of dexamethasone, and within 24 hours of delivery. Serum levels of carboxy terminal pro-peptide of type I pro-collagen (PICP) were measured to monitor the rate of bone formation, and serum levels of cross-linked carboxy terminal telopeptide (ICTP) were measured as a marker of bone resorption. MAIN OUTCOME MEASURES: Changes in the markers of bone turnover following dexamethasone administration. RESULTS: Serum PICP levels dropped 24 hours after dexamethasone therapy (P = 0.001), but partially recovered by 48 hours (P = 0.014) to reach higher than pre-therapy levels at delivery (P = 0.044). Although there were no corresponding changes in the serum levels of ICTP after 24 and 48 hours of therapy, levels increased from pretherapy to delivery (P = 0.006). CONCLUSION: Antenatal corticosteroid therapy leads to a transient suppression of, followed by an increase in, bone formation without any significant alteration in the pattern of bone resorption expected during pregnancy. |
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Authors:
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O Ogueh; G Khastgir; J W Studd; J Jones; J Alaghband-Zadeh; M R Johnson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of obstetrics and gynaecology Volume: 105 ISSN: 0306-5456 ISO Abbreviation: Br J Obstet Gynaecol Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-07-09 Completed Date: 1998-07-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503752 Medline TA: Br J Obstet Gynaecol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 551-5 Citation Subset: AIM; IM |
Affiliation:
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Section of Obstetrics and Gynaecology, Imperial College School of Medicine at Chelsea and Westminster Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Bone Remodeling Collagen Collagen Type I Cross-Linking Reagents Dexamethasone / adverse effects Female Fetal Organ Maturity Glucocorticoids / adverse effects* Humans Infant, Newborn Longitudinal Studies Lung / embryology* Obstetric Labor, Premature Osteoporosis / chemically induced* Peptide Fragments / blood Peptides Pregnancy Prenatal Care Procollagen / blood Prospective Studies Respiratory Distress Syndrome, Newborn / prevention & control* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Collagen Type I; 0/Cross-Linking Reagents; 0/Glucocorticoids; 0/Peptide Fragments; 0/Peptides; 0/Procollagen; 0/collagen type I trimeric cross-linked peptide; 50-02-2/Dexamethasone; 9007-34-5/Collagen |
| Comments/Corrections | |
Comment In:
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BJOG. 2000 Mar;107(3):434-5
[PMID:
10740348
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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