Document Detail


Antenatal corticosteroid therapy and risk of osteoporosis.
MedLine Citation:
PMID:  9637126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the risk of maternal osteoporosis associated with antenatal corticosteroid administration for neonatal respiratory distress syndrome prophylaxis. DESIGN: Prospective longitudinal study. SETTING: Maternity unit of Chelsea and Westminster Hospital, London. POPULATION: Fourteen pregnant women who received dexamethasone therapy for fetal lung maturation in anticipation of delivery before 34 completed weeks of gestation. METHODS: Blood samples were collected before dexamethasone administration, 24 hours and 48 hours after the course of dexamethasone, and within 24 hours of delivery. Serum levels of carboxy terminal pro-peptide of type I pro-collagen (PICP) were measured to monitor the rate of bone formation, and serum levels of cross-linked carboxy terminal telopeptide (ICTP) were measured as a marker of bone resorption. MAIN OUTCOME MEASURES: Changes in the markers of bone turnover following dexamethasone administration. RESULTS: Serum PICP levels dropped 24 hours after dexamethasone therapy (P = 0.001), but partially recovered by 48 hours (P = 0.014) to reach higher than pre-therapy levels at delivery (P = 0.044). Although there were no corresponding changes in the serum levels of ICTP after 24 and 48 hours of therapy, levels increased from pretherapy to delivery (P = 0.006). CONCLUSION: Antenatal corticosteroid therapy leads to a transient suppression of, followed by an increase in, bone formation without any significant alteration in the pattern of bone resorption expected during pregnancy.
Authors:
O Ogueh; G Khastgir; J W Studd; J Jones; J Alaghband-Zadeh; M R Johnson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  105     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-07-09     Completed Date:  1998-07-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  551-5     Citation Subset:  AIM; IM    
Affiliation:
Section of Obstetrics and Gynaecology, Imperial College School of Medicine at Chelsea and Westminster Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Bone Remodeling
Collagen
Collagen Type I
Cross-Linking Reagents
Dexamethasone / adverse effects
Female
Fetal Organ Maturity
Glucocorticoids / adverse effects*
Humans
Infant, Newborn
Longitudinal Studies
Lung / embryology*
Obstetric Labor, Premature
Osteoporosis / chemically induced*
Peptide Fragments / blood
Peptides
Pregnancy
Prenatal Care
Procollagen / blood
Prospective Studies
Respiratory Distress Syndrome, Newborn / prevention & control*
Risk Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type I; 0/Cross-Linking Reagents; 0/Glucocorticoids; 0/Peptide Fragments; 0/Peptides; 0/Procollagen; 0/collagen type I trimeric cross-linked peptide; 50-02-2/Dexamethasone; 9007-34-5/Collagen
Comments/Corrections
Comment In:
BJOG. 2000 Mar;107(3):434-5   [PMID:  10740348 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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