| Antenatal corticosteroid therapy and fetal behaviour: a randomised study of the effects of betamethasone and dexamethasone. | |
| | |
MedLine Citation:
|
PMID: 9386023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To compare the effects of maternal betamethasone and dexamethasone administration on fetal behaviour and fetal heart rate variation. DESIGN: A prospective randomised study of 60 women at increased risk of preterm delivery. OUTCOME MEASURES: Fetal heart rate and its variation, the incidence of fetal body and breathing movements. SETTING: Obstetric unit, University Hospital, Utrecht, The Netherlands. RESULTS: Following maternal betamethasone administration (day 2), fetal heart rate variation was reduced by 19% and fetal body and breathing movements by 49% and 85%, respectively. After dexamethasone treatment there was a significant increase in short term fetal heart rate variation (24%) on day 1. All values returned to baseline on day 4, indicating that no fetal deterioration had occurred during the course of the study period. CONCLUSION: Betamethasone, with probably the greater beneficial effect, has more effects on fetal behaviour and fetal heart rate variation than dexamethasone. When assessing fetal condition, due account needs to be taken of these effects. |
| | |
Authors:
|
E J Mulder; J B Derks; G H Visser |
Related Documents
:
|
1415383 - Screening for congenital heart disease with the four-chamber view of the fetal heart. 3820043 - The potential distribution generated by the fetal heart at the maternal abdomen. 11122273 - Leukaemic small cell variant anaplastic large cell lymphoma during pregnancy. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: British journal of obstetrics and gynaecology Volume: 104 ISSN: 0306-5456 ISO Abbreviation: Br J Obstet Gynaecol Publication Date: 1997 Nov |
Date Detail:
|
Created Date: 1997-12-23 Completed Date: 1997-12-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7503752 Medline TA: Br J Obstet Gynaecol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 1239-47 Citation Subset: AIM; IM |
Affiliation:
|
Department of Obstetrics and Gynaecology, University Hosptial, Utrecht, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Betamethasone
/
therapeutic use* Dexamethasone / therapeutic use* Female Fetal Monitoring Fetal Movement / drug effects* Gestational Age Glucocorticoids / therapeutic use* Heart Rate, Fetal / drug effects* Humans Male Obstetric Labor, Premature / prevention & control Pregnancy Prospective Studies Respiration / drug effects Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Glucocorticoids; 378-44-9/Betamethasone; 50-02-2/Dexamethasone |
| Comments/Corrections | |
Comment In:
|
Br J Obstet Gynaecol. 1997 Nov;104(11):1219-20
[PMID:
9386018
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A randomised controlled comparison of betamethasone with dexamethasone: effects on the antenatal fet...
Next Document: Hyperhomocysteinaemia and protein S deficiency in complicated pregnancies.