Document Detail

Antenatal corticosteroid therapy and fetal behaviour: a randomised study of the effects of betamethasone and dexamethasone.
MedLine Citation:
PMID:  9386023     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare the effects of maternal betamethasone and dexamethasone administration on fetal behaviour and fetal heart rate variation. DESIGN: A prospective randomised study of 60 women at increased risk of preterm delivery. OUTCOME MEASURES: Fetal heart rate and its variation, the incidence of fetal body and breathing movements. SETTING: Obstetric unit, University Hospital, Utrecht, The Netherlands. RESULTS: Following maternal betamethasone administration (day 2), fetal heart rate variation was reduced by 19% and fetal body and breathing movements by 49% and 85%, respectively. After dexamethasone treatment there was a significant increase in short term fetal heart rate variation (24%) on day 1. All values returned to baseline on day 4, indicating that no fetal deterioration had occurred during the course of the study period. CONCLUSION: Betamethasone, with probably the greater beneficial effect, has more effects on fetal behaviour and fetal heart rate variation than dexamethasone. When assessing fetal condition, due account needs to be taken of these effects.
E J Mulder; J B Derks; G H Visser
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  104     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-23     Completed Date:  1997-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1239-47     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, University Hosptial, Utrecht, The Netherlands.
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MeSH Terms
Betamethasone / therapeutic use*
Dexamethasone / therapeutic use*
Fetal Monitoring
Fetal Movement / drug effects*
Gestational Age
Glucocorticoids / therapeutic use*
Heart Rate, Fetal / drug effects*
Obstetric Labor, Premature / prevention & control
Prospective Studies
Respiration / drug effects
Risk Factors
Reg. No./Substance:
0/Glucocorticoids; 378-44-9/Betamethasone; 50-02-2/Dexamethasone
Comment In:
Br J Obstet Gynaecol. 1997 Nov;104(11):1219-20   [PMID:  9386018 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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