Document Detail

Antenatal betamethasone treatment has a persisting influence on infant HPA axis regulation.
MedLine Citation:
PMID:  16467857     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the consequences of antenatal betamethasone (AB) exposure on postnatal stress regulation. STUDY DESIGN: Fourteen AB exposed infants born at 28-30 weeks' gestation were assessed in the NICU during postnatal week 1 and at 34 weeks postconception. Nine infants born at 34 weeks gestation without AB treatment were evaluated as a postconceptional age comparison group. Salivary cortisol, heart rate, and behavior were measured at baseline and in response to a heelstick blood draw. RESULTS: Repeated measures ANOVAs revealed that both groups displayed an increase in heart rate and behavioral distress in response to the stressor. The cortisol response, however, was blunted in AB-treated infants at both assessments. CONCLUSION: AB treatment has consequences for hypothalamic-pituitary-adrenal (HPA) axis regulation that persist for at least four to six weeks after birth, indicating that studies of long-term effects are warranted.
E P Davis; E L Townsend; M R Gunnar; S F Guiang; R C Lussky; R F Cifuentes; M K Georgieff
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  26     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-22     Completed Date:  2006-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-53     Citation Subset:  IM    
Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92868, USA.
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MeSH Terms
Analysis of Variance
Apgar Score
Betamethasone / adverse effects*,  therapeutic use
Case-Control Studies
Cohort Studies
Dose-Response Relationship, Drug
Drug Administration Schedule
Follow-Up Studies
Gestational Age
Heart Rate / drug effects
Hydrocortisone / metabolism
Infant, Newborn
Infant, Premature*
Intensive Care Units, Neonatal
Pituitary-Adrenal Function Tests
Pituitary-Adrenal System / drug effects*,  physiopathology
Prenatal Exposure Delayed Effects*
Reference Values
Stress, Psychological
Time Factors
Reg. No./Substance:
378-44-9/Betamethasone; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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