| Antenatal associations with lung maturation and infection. | |
| | |
MedLine Citation:
|
PMID: 15861169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Chronic clinically unapparent chorioamnionitis is a common antenatal exposure for very preterm infants, and these infants have variable degrees of lung maturation and a high risk of developing bronchopulmonary dysplasia. Exposure of fetal sheep to intra-amniotic endotoxin or IL-1alpha induces chorioamnionitis and lung injury (decreased alveolarization and microvascular injury), which resolves to a phenotype of striking lung maturation (increased surfactant, improved gas exchange and lung mechanics). The immune responses of the fetus also are suppressed or induced (matured) in time and dose-dependent ways by either chorioamnionitis or antenatal corticosteroids. These experimental observations contribute to explanations of why preterm infants have variable degrees of lung maturation at birth and unpredictably develop bronchopulmonary dysplasia BPD. |
| | |
Authors:
|
Alan H Jobe |
Related Documents
:
|
19902199 - Pulmonary interstitial glycogenosis. 14980279 - Postnatal steroids and chronic lung disease in the newborn. 19160189 - Late (>7 days) postnatal corticosteroids for chronic lung disease in preterm infants. 9462189 - Early increase of tnf alpha and il-6 in tracheobronchial aspirate fluid indicator of su... 9035199 - Familial interstitial lung disease in children: response to chloroquine treatment in on... 8941999 - Interleukin 8 and granulocyte elastase alpha 1 proteinase inhibitor complex in the trac... 4004159 - Seizures and cerebral infarction in the full-term newborn. 19902199 - Pulmonary interstitial glycogenosis. 20509959 - Breastfeeding and weaning practices among hong kong mothers: a prospective study. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 25 Suppl 2 ISSN: 0743-8346 ISO Abbreviation: J Perinatol Publication Date: 2005 May |
Date Detail:
|
Created Date: 2005-04-29 Completed Date: 2005-09-01 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
|
Languages: eng Pagination: S31-5 Citation Subset: IM |
Affiliation:
|
Division Pulmonary Biology, Cincinnati Children's Hospital, OH 45229, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bronchopulmonary Dysplasia / etiology* Chorioamnionitis / complications* Female Fetal Organ Maturity* Humans Infant, Newborn Lung / embryology* Pregnancy Respiratory Distress Syndrome, Newborn / etiology* |
| Grant Support | |
ID/Acronym/Agency:
|
HD-12714/HD/NICHD NIH HHS; HL65397/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inotrope, lusitrope, and pressor use in neonates.
Next Document: Surfactant protein C: basics to bedside.