Document Detail

Antenatal associations with lung maturation and infection.
MedLine Citation:
PMID:  15861169     Owner:  NLM     Status:  MEDLINE    
Chronic clinically unapparent chorioamnionitis is a common antenatal exposure for very preterm infants, and these infants have variable degrees of lung maturation and a high risk of developing bronchopulmonary dysplasia. Exposure of fetal sheep to intra-amniotic endotoxin or IL-1alpha induces chorioamnionitis and lung injury (decreased alveolarization and microvascular injury), which resolves to a phenotype of striking lung maturation (increased surfactant, improved gas exchange and lung mechanics). The immune responses of the fetus also are suppressed or induced (matured) in time and dose-dependent ways by either chorioamnionitis or antenatal corticosteroids. These experimental observations contribute to explanations of why preterm infants have variable degrees of lung maturation at birth and unpredictably develop bronchopulmonary dysplasia BPD.
Alan H Jobe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  25 Suppl 2     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-29     Completed Date:  2005-09-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S31-5     Citation Subset:  IM    
Division Pulmonary Biology, Cincinnati Children's Hospital, OH 45229, USA.
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MeSH Terms
Bronchopulmonary Dysplasia / etiology*
Chorioamnionitis / complications*
Fetal Organ Maturity*
Infant, Newborn
Lung / embryology*
Respiratory Distress Syndrome, Newborn / etiology*
Grant Support

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