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Antenatal antibiotic exposure in preterm infants with necrotizing enterocolitis.
MedLine Citation:
PMID:  22157626     Owner:  NLM     Status:  Publisher    
Objective:To determine whether an association exists between antenatal antibiotic exposure and incidence of necrotizing enterocolitis (NEC) in low birth weight infants.Study Design:A retrospective case-control study was performed on all infants with a diagnosis of NEC born at our institition between 1988 and 2006. Medical histories of all infants with a diagnosis of NEC Bell's stage IIA and matched controls without NEC were reviewed. Maternal and neonatal characteristics were compared using the Mantel-Haenszel chi-square procedure, and logistic regression models were constructed to account for confounding.Result:Clinical data for 97 matched pairs were analyzed. The adjusted odds ratio (OR) for antenatal exposure to ampicillin was significantly greater for infants who developed NEC (OR 2.3, 95% confidence interval 1.1, 4.8, P=0.003) than for control infants.Conclusion:Infants who developed NEC were more likely to have a history of in utero exposure to ampicillin in the immediate antepartum period than infants who did not develop NEC.Journal of Perinatology advance online publication, 8 December 2011; doi:10.1038/jp.2011.180.
A S Weintraub; L Ferrara; L Deluca; E Moshier; R S Green; E Oakman; M-J Lee; L Rand
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-08
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  -     ISSN:  1476-5543     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Newborn Medicine, Department of Pediatrics, Kravis Children's Hospital, The Mount Sinai School of Medicine, New York, NY, USA.
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