Document Detail


Antenatal ambroxol effects on surfactant pool size and postnatal lung function in preterm ventilated rabbits.
MedLine Citation:
PMID:  1391276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Following maternal treatments with 50 mg/kg/day ambroxol for 2 or 3 days before delivery at 28 days gestation, preterm rabbits were ventilated to evaluate lung function. Subsequently, surfactant saturated phosphatidylcholine (SatPC) pool sizes were measured. One half of the ambroxol treated and control rabbits were given surfactant at delivery. Although surfactant improved lung function comparably for control and ambroxol treated rabbits, ambroxol treatments did not change ventilatory pressure requirements, compliances, or the recovery of intravascular labeled albumin in the lungs. Ambroxol treatments tended to increase lung volumes as evaluated by pressure-volume curves. The ambroxol treatments significantly increased lung tissue SatPC by 22%, but there were no changes in alveolar SatPC pool values. These results do not indicate a large effect of ambroxol on lung function in preterm rabbits.
Authors:
B Sun; E Rider; M Ikegami; A Jobe
Related Documents :
19641856 - Low-pressure lipase-catalyzed production of mono- and diglycerides with and without n-b...
1828856 - Reactive hyperemia in term neonates and adults--a laser doppler fluxmetry study of skin...
8208596 - Cardiorespiratory and stress hormone responses during first dose surfactant administrat...
560176 - Alterations in blood pressure during exchange transfusion.
7329986 - Postsynaptic adrenergic unresponsiveness in hypotensive haemodialysis patients.
11553016 - New perspectives on the role of aldosterone excess in cardiovascular disease.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of the neonate     Volume:  62     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1992  
Date Detail:
Created Date:  1992-11-23     Completed Date:  1992-11-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  55-62     Citation Subset:  IM    
Affiliation:
Perinatal Laboratories, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance 90505.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Ambroxol / pharmacology*
Animals
Animals, Newborn
Female
Fetal Organ Maturity / drug effects
Lung / drug effects*,  embryology,  physiology
Lung Volume Measurements
Maternal-Fetal Exchange
Pregnancy
Pulmonary Surfactants / metabolism*
Rabbits
Grant Support
ID/Acronym/Agency:
HD-11934/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Pulmonary Surfactants; 18683-91-5/Ambroxol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Transfer of 125I-albumin from blood to brain in newborn rats and the effect of hyperbilirubinemia on...
Next Document:  An increased ability to generate hydrogen peroxide in certain polymorphonuclear leukocytes in neonat...