Document Detail

Antenatal ambroxol effects on surfactant pool size and postnatal lung function in preterm ventilated rabbits.
MedLine Citation:
PMID:  1391276     Owner:  NLM     Status:  MEDLINE    
Following maternal treatments with 50 mg/kg/day ambroxol for 2 or 3 days before delivery at 28 days gestation, preterm rabbits were ventilated to evaluate lung function. Subsequently, surfactant saturated phosphatidylcholine (SatPC) pool sizes were measured. One half of the ambroxol treated and control rabbits were given surfactant at delivery. Although surfactant improved lung function comparably for control and ambroxol treated rabbits, ambroxol treatments did not change ventilatory pressure requirements, compliances, or the recovery of intravascular labeled albumin in the lungs. Ambroxol treatments tended to increase lung volumes as evaluated by pressure-volume curves. The ambroxol treatments significantly increased lung tissue SatPC by 22%, but there were no changes in alveolar SatPC pool values. These results do not indicate a large effect of ambroxol on lung function in preterm rabbits.
B Sun; E Rider; M Ikegami; A Jobe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of the neonate     Volume:  62     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1992  
Date Detail:
Created Date:  1992-11-23     Completed Date:  1992-11-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  55-62     Citation Subset:  IM    
Perinatal Laboratories, Harbor-UCLA Medical Center, UCLA School of Medicine, Torrance 90505.
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MeSH Terms
Ambroxol / pharmacology*
Animals, Newborn
Fetal Organ Maturity / drug effects
Lung / drug effects*,  embryology,  physiology
Lung Volume Measurements
Maternal-Fetal Exchange
Pulmonary Surfactants / metabolism*
Grant Support
Reg. No./Substance:
0/Pulmonary Surfactants; 18683-91-5/Ambroxol

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