Document Detail


Antenatal glucocorticoid treatment affects preterm infants' S100B urine concentration in a dose-dependent manner.
MedLine Citation:
PMID:  20570670     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Maternal glucocorticoid (GC) treatment is widely used to prevent lung immaturity in preterm infants. There is growing evidence that GCs may be detrimental to the Central Nervous System (CNS). We investigated whether antenatal GC administration affects CNS function in a dose-dependent manner by measuring urine concentrations of a well-established brain damage marker, S100B. METHODS: We conducted a case-control-study in 70 preterm infants (1 GC vs 1 control) whose mothers received a complete GC-course (GC2, n=16), half-course (GC1, n=19), and controls (n=35). At four predetermined time-points, in the first 72 h from birth, we assessed S100B urine concentrations, using a commercially available immunoluminometric assay (Lia-mat Sangtec 100, AB Sangtec Medical, Bromma, Sweden). Data were correlated with primary neonatal outcomes (incidence of respiratory distress syndrome, length of ventilatory support and hospital stay, incidence of intraventricular hemorrhage, adverse 7th day neurological follow-up and neonatal death). RESULTS: S100B in GC2 group at all monitoring time-points was significantly lower (P<0.01) than controls and GC1 group, while no differences (P>0.05) were evident between controls and GC1 group. No significant differences (P>0.05) were shown in primary outcomes between half or complete GC-course treated groups. CONCLUSION: S100B levels of infants antenatally treated with GCs differed in a dose-dependent manner. Data on primary outcomes suggest that lowering antenatal GC-course may be less detrimental for brain without affecting lung maturation. Further clinical trials are needed to elucidate the low GC-course issue.
Authors:
Andrea Sannia; Francesco M Risso; Laura D Serpero; Rosanna Frulio; Fabrizio Michetti; Raul Abella; Alessandro Frigiola; Alessandro Giamberti; Diego Gazzolo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-04
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  411     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1539-41     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
Dept. of Neonatology Obstetrics and Neuroscience, G Gaslini Children's University Hospital, Genoa, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / urine
Case-Control Studies
Central Nervous System / drug effects
Dose-Response Relationship, Drug
Female
Glucocorticoids / adverse effects*,  therapeutic use
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / chemically induced*
Lung / drug effects,  growth & development
Nerve Growth Factors / urine*
Pregnancy
S100 Proteins / urine*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Glucocorticoids; 0/Nerve Growth Factors; 0/S-100 calcium-binding protein beta subunit; 0/S100 Proteins

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