Document Detail

Antenatal glucocorticoid exposure and long-term alterations in aortic function and glucose metabolism.
MedLine Citation:
PMID:  22508917     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Animal studies have demonstrated long-term effects of in utero glucocortcoid exposure on vascular development and glucose metabolism. We hypothesized that there would be a similar impact in humans.
METHODS: One hundred and two young adults born preterm aged 23 to 28 years, with prospective data collection from birth, and 95 adults born term after uncomplicated pregnancies underwent cardiovascular MRI. We compared cardiac and aortic structure and function, as well as cardiovascular risk profile, in a nested case-control study of 16 participants exposed to antenatal steroids and 32 who were not, but with otherwise similar perinatal care. Outcomes were compared with normal ranges in those born term.
RESULTS: Adults whose mothers had received antenatal steroids had decreased ascending aortic distensibility (9.88 ± 3.21 vs 13.62 ± 3.88 mm Hg(-1) × 10(3), P = .002) and increased aortic arch pulse wave velocity (5.45 ± 1.41 vs 4.47 ± 0.91 m/s, P = .006). The increase in stiffness was equivalent to that of term adults a decade older. Those who had in utero exposure to antenatal steroids also had significant differences in homeostatic model assessments for β-cell function (P = .010), but in multiple regression analysis this did not explain the impact of steroids on aortic function.
CONCLUSIONS: Antenatal glucocorticoid exposure in preterm infants is associated with increased aortic arch stiffness and altered glucose metabolism in early adulthood.
Brenda A Kelly; Adam J Lewandowski; Stephanie A Worton; Esther F Davis; Merzaka Lazdam; Jane Francis; Stefan Neubauer; Alan Lucas; Atul Singhal; Paul Leeson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-16
Journal Detail:
Title:  Pediatrics     Volume:  129     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-02     Completed Date:  2012-06-21     Revised Date:  2014-06-10    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1282-90     Citation Subset:  AIM; IM    
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MeSH Terms
Aorta, Thoracic / drug effects*
Blood Flow Velocity / drug effects
Blood Glucose / metabolism*
Blood Pressure / drug effects
Case-Control Studies
Glucocorticoids / administration & dosage,  adverse effects*
Insulin-Secreting Cells / drug effects*
Prenatal Exposure Delayed Effects / diagnosis*
Vascular Resistance / drug effects
Young Adult
Grant Support
090532//Wellcome Trust; FS/06/024//British Heart Foundation; FS/11/65/28865//British Heart Foundation
Reg. No./Substance:
0/Blood Glucose; 0/Glucocorticoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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