| Antenatal diagnosis of fetal genotype determines if maternal hyperglycemia due to a glucokinase mutation requires treatment. | |
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MedLine Citation:
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PMID: 22773699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: In women with hyperglycemia due to heterozygous glucokinase (GCK) mutations, the fetal genotype determines its growth. If the fetus inherits the mutation, birth weight is normal when maternal hyperglycemia is not treated, whereas intensive treatment may adversely reduce fetal growth. However, fetal genotype is not usually known antenatally, making treatment decisions difficult. HISTORY AND EXAMINATION: We report two women with gestational diabetes mellitus resulting from GCK mutations with hyperglycemia sufficient to merit treatment. INVESTIGATION: In both women, DNA from chorionic villus sampling, performed after high-risk aneuploidy screening, showed the fetus had inherited the GCK mutation. Therefore, maternal hyperglycemia was not treated. Both offspring had a normal birth weight and no peripartum complications. CONCLUSIONS: In pregnancies where the mother has hyperglycemia due to a GCK mutation, knowing the fetal GCK genotype guides the management of maternal hyperglycemia. Fetal genotyping should be performed when fetal DNA is available from invasive prenatal diagnostic testing. |
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Authors:
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Ali J Chakera; Victoria L Carleton; Sian Ellard; Jencia Wong; Dennis K Yue; Jason Pinner; Andrew T Hattersley; Glynis P Ross |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2012-07-06 |
Journal Detail:
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Title: Diabetes care Volume: 35 ISSN: 1935-5548 ISO Abbreviation: Diabetes Care Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-08-27 Completed Date: 2013-01-11 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: United States |
Other Details:
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Languages: eng Pagination: 1832-4 Citation Subset: IM |
Affiliation:
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Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Diabetes, Gestational / genetics Female Genotype Glucokinase / genetics* Humans Hyperglycemia / genetics* Mutation Pregnancy Prenatal Diagnosis / methods* |
| Chemical | |
Reg. No./Substance:
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EC 2.7.1.2/Glucokinase |
| Comments/Corrections | |
Comment In:
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Diabetes Care. 2013 Jan;36(1):e14
[PMID:
23264297
]
Diabetes Care. 2013 Jan;36(1):e15 [PMID: 23264298 ] Diabetes Care. 2012 Sep;35(9):1811-3 [PMID: 22923681 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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