Document Detail

Antenatal corticosteroids prior to 24 weeks' gestation and neonatal outcome of extremely low birth weight infants.
MedLine Citation:
PMID:  19544249     Owner:  NLM     Status:  MEDLINE    
We sought to determine if antenatal corticosteroid treatment administered prior to 24 weeks' gestation influences neonatal morbidity and mortality in extremely low-birth-weight infants. A retrospective review was performed of all singleton pregnancies treated with one complete course of antenatal corticosteroids prior to 24 weeks' gestation and delivered between 23(0)/(7) and 25(6)/(7) weeks. These infants were compared with similar gestational-age controls. There were no differences in gender, race, birth weight, and gestational age between the groups. Infants exposed to antenatal corticosteroids had lower mortality (29.3% versus 62.9%, P = 0.001) and grade 3 or 4 intraventricular hemorrhage (IVH; 16.7% versus 36%, P < 0.05; relative risk [RR]: 2.16). Grade 3 and 4 IVH was associated with significantly lower survival probability as compared with no IVH or grade 1 and 2 IVH (P < 0.001, RR: 10.6, 95% confidence interval [CI]: 4.4 to 25.6). Antenatal steroid exposure was associated with a 62% decrease in the hazard rate compare with those who did not receive antenatal steroids after adjusting for IVH grade (Cox proportional hazard model, hazard ratio 0.38, 95% CI: 0.152 to 0.957, P = 0.04). The rates of premature rupture of membranes and chorioamnionitis were higher for infants exposed to antenatal corticosteroids. Exposure to a single course of antenatal corticosteroids prior to 24 weeks' gestation was associated with reduction of the risk of severe IVH and neonatal mortality for extremely low-birth-weight infants.
Soraya Abbasi; Corrina Oxford; Jeffrey Gerdes; Harish Sehdev; Jack Ludmir
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-06-19
Journal Detail:
Title:  American journal of perinatology     Volume:  27     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-24     Completed Date:  2010-03-16     Revised Date:  2011-01-20    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM    
Copyright Information:
Thieme Medical Publishers.
Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
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MeSH Terms
Gestational Age
Glucocorticoids / administration & dosage*
Infant Mortality*
Infant, Extremely Low Birth Weight*
Infant, Newborn
Pregnancy Outcome
Treatment Outcome
Reg. No./Substance:
Erratum In:
Am J Perinatol. 2011 Jan;28(1):87-8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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