| Antenatal betamethasone alters vascular reactivity in adult female ovine cerebral arteries. | |
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MedLine Citation:
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PMID: 20581740 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the use of antenatal glucocorticoids has resulted in decreased neonatal morbidity/mortality, recent animal studies have raised concerns regarding adverse effects of these medications on postnatal cardiovascular function. We hypothesized that antenatal betamethasone (Beta) exposure alters cerebral vascular reactivity in adult female sheep. We observed that K-induced constriction was comparable in middle cerebral artery (MCA) from Beta-exposed animals and age-matched controls. Pressure-induced constriction was significantly attenuated in MCA from Beta-exposed compared with control sheep. Inhibition of NOS significantly augmented pressure-induced constriction in MCA from both Beta-exposed and control sheep, whereas cyclooxygenase (COX) inhibition augmented pressure-induced constriction only in MCA from Beta-exposed sheep. Furthermore, NOS and COX inhibition significantly attenuated bradykinin (BK)-induced dilation in MCA from both Beta-exposed and control sheep. However, there seemed to be a greater contribution of both NOS and COX to BK-induced dilation in Beta-exposed compared with control MCA. Our findings demonstrate that fetal exposure to a clinically relevant course of Beta alters cerebral vascular tone and reactivity in adult female sheep. |
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Authors:
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Delrae M Eckman; Brady A Kerr; Mamta Fuloria; Steve A Simandle; Suzanne E Watt; James C Rose; Jorge P Figueroa |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Pediatric research Volume: 68 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2011-01-11 Revised Date: 2011-10-19 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 344-8 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. deckman@wfubmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Betamethasone / administration & dosage*, toxicity Blood Pressure Cyclooxygenase Inhibitors / pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors / pharmacology Female Glucocorticoids / administration & dosage*, toxicity Middle Cerebral Artery / drug effects*, enzymology Nitric Oxide Synthase / antagonists & inhibitors, metabolism Pregnancy Prenatal Exposure Delayed Effects* Sheep Vasoconstriction / drug effects* Vasodilation / drug effects* Vasodilator Agents / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL068728/HL/NHLBI NIH HHS; P01 HD047584/HD/NICHD NIH HHS; P01 HD047584-02/HD/NICHD NIH HHS; P01 HD047584-03/HD/NICHD NIH HHS; R01 HD017644-25/HD/NICHD NIH HHS; R01 HL068728-07/HL/NHLBI NIH HHS; R01 HL068728-08/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase Inhibitors; 0/Enzyme Inhibitors; 0/Glucocorticoids; 0/Vasodilator Agents; 378-44-9/Betamethasone; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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