Document Detail

Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia.
MedLine Citation:
PMID:  11889239     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess the diagnostic specificity of MRI-defined hippocampal atrophy for AD among individuals with a variety of pathologically confirmed conditions associated with dementia as well as changes attributable to typical aging, and to measure correlations among premortem MRI measurements of hippocampal atrophy, mental status examination performance, and the pathologic stage of AD.
METHODS: An unselected series of 67 individuals participating in the Mayo Alzheimer's Disease Research Center/Alzheimer's Disease Patient Registry who had undergone a standardized antemortem MRI study and also postmortem examination were identified. Hippocampal volumes were measured from antemortem MRI. Each postmortem specimen was assigned a pathologic diagnosis and in addition, the severity of AD pathology was staged using the method of Braak and Braak.
RESULTS: Individuals with an isolated pathologic diagnosis of AD, hippocampal sclerosis, frontotemporal degeneration, and neurofibrillary tangle--only degeneration usually had substantial hippocampal atrophy, while those with changes of typical aging did not. Among all 67 subjects, correlations (all p < 0.001) were observed between hippocampal volume and Braak and Braak stage (r = -0.39), between hippocampal volume and Mini-Mental State Examination (MMSE) score (r = 0.60), and between MMSE score and Braak and Braak stage (r = -0.41).
CONCLUSIONS: Hippocampal atrophy, while not specific for AD, was a fairly sensitive marker of the pathologic AD stage (particularly among subjects with isolated AD pathology [r = -0.63, p = 0.001]) and consequent cognitive status.
C R Jack; D W Dickson; J E Parisi; Y C Xu; R H Cha; P C O'Brien; S D Edland; G E Smith; B F Boeve; E G Tangalos; E Kokmen; R C Petersen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  58     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-12     Completed Date:  2002-04-19     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  750-7     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Aging / pathology*
Alzheimer Disease / diagnosis*,  pathology*
Dementia / pathology*
Hippocampus / pathology*
Magnetic Resonance Imaging
Middle Aged
Sensitivity and Specificity
Statistics as Topic
Grant Support
AG06786/AG/NIA NIH HHS; AG11378/AG/NIA NIH HHS; AG16574/AG/NIA NIH HHS; NS29059/NS/NINDS NIH HHS; P50 AG016574/AG/NIA NIH HHS; P50 AG016574-049004/AG/NIA NIH HHS; R01 AG011378/AG/NIA NIH HHS; R01 AG011378-10/AG/NIA NIH HHS; U01 AG006786/AG/NIA NIH HHS; U01 AG006786-18/AG/NIA NIH HHS

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