Document Detail

Antegrade selective cerebral perfusion in thoracic aorta surgery: safety of moderate hypothermia.
MedLine Citation:
PMID:  17254793     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Although antegrade selective cerebral perfusion (ASCP) has been demonstrated to be the best method of protection of brain ischemia during aortic arch surgery, there is no consensus regarding optimal temperature during ASCP. The study analyzed the outcomes of aortic surgery using ASCP at different degree of systemic hypothermia. METHODS: Between November 1996 and November 2005, 305 patients underwent thoracic aorta surgery using ASCP. Patients were divided into two groups according to the lowest systemic temperature: moderate systemic hypothermia (> or =25 degrees C) was used in 189 patients (group A), and a deeper hypothermia (<25 degrees C) in 116 patients (group B). One hundred and five patients suffered from acute type A aortic dissection. RESULTS: The extension of aortic replacement was significantly larger in group A, while the average ASCP time was not different between groups (63+/-37.7min group A, 58.6+/-35.6min group B; p=0.314). The 30-day mortality rate was 12.7% in group A and 13.8% in group B (p=0.862). Permanent neurologic deficits occurred in eight patients (2.6%) without significant differences between groups (3.1% group A vs 1.7% group B; p=0.715). Twenty-five patients (8.2%) suffered from temporary neurologic dysfunction (7.9% group A vs 8.6% group B; p=0.833). CONCLUSIONS: In our experience, ASCP was a safe technique for thoracic aorta surgery allowing complex aortic repairs to be performed with good results in terms of hospital mortality and neurologic outcomes. The fact that there was no difference between the two groups suggests that moderate systemic hypothermia (26 degrees C) appears to be a safe and sufficient tool for brain protection. Moreover, the well known hypothermia-related side effects may be avoided.
Davide Pacini; Alessandro Leone; Luca Di Marco; Daniele Marsilli; Fedaa Sobaih; Simone Turci; Valeria Masieri; Roberto Di Bartolomeo
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2007-01-23
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  31     ISSN:  1010-7940     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-19     Completed Date:  2007-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  618-22     Citation Subset:  IM    
Department of Cardiac Surgery, S Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
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MeSH Terms
Acute Disease
Aorta, Thoracic / surgery*
Aortic Aneurysm / mortality,  physiopathology,  surgery
Aortic Diseases / mortality,  physiopathology,  surgery*
Body Temperature / physiology
Brain Ischemia / prevention & control*
Cardiopulmonary Bypass / methods
Chronic Disease
Hypothermia, Induced / adverse effects,  methods*
Middle Aged
Perfusion / methods*
Postoperative Complications / etiology
Treatment Outcome
Vascular Surgical Procedures / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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