Document Detail

Antecedents of schizophrenia and affective illness. Obstetric complications.
MedLine Citation:
PMID:  7663821     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This exploratory study seeks to generate new hypotheses about the relationship between obstetric complications and schizophrenia. METHOD: The British Perinatal Mortality Survey represents 98% of all births during one week in March 1958 in Great Britain. Present State Examination (PSE), Catego diagnoses of narrowly defined schizophrenia (n = 49), broadly defined schizophrenia (n = 79), affective psychosis (n = 44) and neurosis (n = 93) were derived from case notes for all cohort members. The remainder of the cohort, surviving the perinatal period, acted as controls (n = 16 812). Variables in the British Perinatal Mortality Survey were grouped into five categories: the physique/lifestyle of the mother (including demographic characteristics), her obstetric history, the current pregnancy, the delivery and the condition of the baby. RESULTS: There were 7/17 significant differences in maternal physique/lifestyle and obstetric history between the births of schizophrenics and controls, compared to 4/40 comparisons of somatic variables relating to pregnancy, birth and the condition of the baby. This compares with 4/17 and 7/40 for affective psychotics and a total of 4/57 differences for all categories of variables when neurotics were contrasted with controls. CONCLUSIONS: The purported increased risk of obstetric complications in schizophrenics may result from the physique/lifestyle of their mothers.
A Sacker; D J Done; T J Crow; J Golding
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  166     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-10-10     Completed Date:  1995-10-10     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  734-41     Citation Subset:  IM    
Psychology Division, University of Hertfordshire, Hatfield, Herts.
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MeSH Terms
Affective Disorders, Psychotic / diagnosis,  psychology*
Brain Damage, Chronic / diagnosis,  psychology*
Child of Impaired Parents / psychology
Cohort Studies
Delirium, Dementia, Amnestic, Cognitive Disorders / diagnosis,  psychology
Great Britain
Infant, Newborn
Life Style
Neurotic Disorders / diagnosis,  psychology
Obstetric Labor Complications / diagnosis,  psychology*
Prenatal Exposure Delayed Effects
Risk Factors
Schizophrenia / diagnosis*
Schizophrenic Psychology*
Comment In:
Br J Psychiatry. 1995 Nov;167(5):694-5; author reply 696-7   [PMID:  8564335 ]
Br J Psychiatry. 1995 Nov;167(5):695-6; author reply 696-7   [PMID:  8564336 ]

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