Document Detail

Antecedents of cerebral palsy in very low-birth weight infants.
MedLine Citation:
PMID:  10863651     Owner:  NLM     Status:  MEDLINE    
Research from the last two decades provides directions for efforts to prevent CP in VLBW infants. The pathogenesis of CP seems to involve factors operating both during pregnancy and in the neonatal period. The most important prenatal factor appears to be intrauterine infection. Perinatal infection and other risk factors, such as the death of a co-twin, placental abruption, and cerebral ischemia, could trigger a cytokine cascade resulting in damage to the developing brain. The low frequency of intrauterine infection in mothers with preeclampsia might explain the apparent protective effect of this disorder. If the brain damage attributed to intrauterine infection and other risk factors involves cytokines as intermediates, then blockade of the proinflammatory cascade or promotion of endogenous inhibitors might prevent CP. Other potentially preventive strategies include corticosteroids given to mothers (but not those given to neonates) and thyroid hormone.
T M O'Shea; O Dammann
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  27     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-10-02     Completed Date:  2000-10-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  285-302     Citation Subset:  IM    
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
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MeSH Terms
Abruptio Placentae / complications
Anti-Inflammatory Agents / therapeutic use
Brain Ischemia / complications
Cerebral Palsy / drug therapy,  etiology*,  prevention & control
Cytokines / immunology
Diseases in Twins / epidemiology
Hypothyroidism / complications
Infant, Newborn
Infant, Very Low Birth Weight*
Pre-Eclampsia / complications
Pregnancy Complications, Infectious
Risk Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Cytokines; 0/Steroids

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