Document Detail


Ante mortem cerebral amino acid concentrations indicate selective degeneration of glutamate-enriched neurons in Alzheimer's disease.
MedLine Citation:
PMID:  1980143     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is little information about major constituents of the brain in Alzheimer's disease. In the case of amino acids most of the previous data are contradictory. These have been interpreted in an anatomic and neurotransmitter as well as a metabolic context. To help clarify this, the contents of 14 amino acids and ethanolamine were determined in samples of neocortex from diagnostic craniotomies of 15 demented patients (10 with Alzheimer's disease) and other neurosurgical procedures (57 patients, 18 with intractable depression). A comprehensive survey of the effects of possible complicating factors on the concentrations of amino acids showed that artefacts were few; this was in contrast to a post mortem series of brains (16 with Alzheimer's disease and 16 controls; six regions assayed). We have used the ante mortem data to provide the basis for an accurate comparison of amino acid values between Alzheimer and control samples. In Alzheimer's disease, the mean contents of many amino acids were slightly higher (sum of the increases of those significantly affected was 15 nmol/mg protein) whereas glutamate content alone was significantly reduced (by 16 nmol/mg protein). This was not a feature of depression or a group of patients with other dementias. Glutamate content of Alzheimer samples was related to pyramidal neuron density in cortical layer III. These alterations were detected relatively early during the course of Alzheimer's disease and are considered to be due to loss of corticocortical glutamatergic association pathways.
Authors:
S L Lowe; D M Bowen; P T Francis; D Neary
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience     Volume:  38     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  1990  
Date Detail:
Created Date:  1991-02-19     Completed Date:  1991-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  571-7     Citation Subset:  IM    
Affiliation:
Miriam Marks Department of Neurochemistry, University of London, U.K.
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / metabolism*,  pathology
Amino Acids / metabolism*
Brain / metabolism*
Glutamates / metabolism*
Glutamic Acid
Humans
Male
Middle Aged
Nerve Degeneration*
Neurons / metabolism*,  physiology
Osmolar Concentration
Postmortem Changes
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Glutamates; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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