| Antagonists and agonists at the glycine site of the NMDA receptor for therapeutic interventions. | |
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MedLine Citation:
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PMID: 12932897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For decades neuroreceptor research has focused on the development of NMDA glycine-site antagonists, after Johnson and Ascher found out in 1987 about the co-agonistic character of this achiral amino acid at the NMDA receptor. Contrary to the inhibitory glycine receptor (glycine(A)) the glycine binding site on the NMDA receptor (glycine(B)) is strychnine-insensitive. A great diversity of diseases showing a disturbed glutamate neurotransmission have been linked to the NMDA receptor. Glycine site antagonists have been investigated for acute diseases like stroke and head trauma as well as chronic ones like dementia and chronic pain. |
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Authors:
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Michaela Jansen; Gerd Dannhardt |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: European journal of medicinal chemistry Volume: 38 ISSN: 0223-5234 ISO Abbreviation: Eur J Med Chem Publication Date: 2003 Jul-Aug |
Date Detail:
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Created Date: 2003-08-22 Completed Date: 2004-11-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0420510 Medline TA: Eur J Med Chem Country: France |
Other Details:
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Languages: eng Pagination: 661-70 Citation Subset: IM |
Affiliation:
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Department of Medicinal and Pharmaceutical Chemistry, Institute of Pharmacy, Johannes Gutenberg-University of Mainz, Staudinger Weg 5, 55099, Mainz, Germany. mjansen@uni-mainz.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticonvulsants / therapeutic use Binding Sites Dementia / drug therapy Epilepsy / drug therapy Excitatory Amino Acid Antagonists / pharmacology, therapeutic use Glycine / agonists, antagonists & inhibitors, chemistry Humans Memantine / therapeutic use Neuroprotective Agents / pharmacology*, therapeutic use Pain / drug therapy Receptors, N-Methyl-D-Aspartate / agonists*, antagonists & inhibitors*, chemistry Schizophrenia / drug therapy Stroke / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Excitatory Amino Acid Antagonists; 0/Neuroprotective Agents; 0/Receptors, N-Methyl-D-Aspartate; 19982-08-2/Memantine; 56-40-6/Glycine |
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