| Antagonists of IAP proteins as cancer therapeutics. | |
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MedLine Citation:
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PMID: 20685035 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Inhibitor of apoptosis (IAP) proteins play pivotal roles in cellular survival by blocking apoptosis, modulating signal transduction, and affecting cellular proliferation. Through their interactions with inducers and effectors of apoptosis IAP proteins can effectively suppress apoptosis triggered by diverse stimuli including death receptor signaling, irradiation, chemotherapeutic agents, or growth factor withdrawal. Evasion of apoptosis, in part due to the action of IAP proteins, enhances resistance of cancer cells to treatment with chemotherapeutic agents and contributes to tumor progression. Additionally, IAP genes are known to be subject to amplification, mutation, and chromosomal translocation in human malignancies and autoimmune diseases. In this review we will discuss the role of IAP proteins in cancer and the development of antagonists targeting IAP proteins for cancer treatment. |
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Authors:
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Jasmin N Dynek; Domagoj Vucic |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-8-2 |
Journal Detail:
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Title: Cancer letters Volume: - ISSN: 1872-7980 ISO Abbreviation: - Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-8-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Protein Engineering, Genentech, Inc., South San Francisco, CA 94080, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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