Document Detail

Antagonistic effects of naloxone on CCK-octapeptide induced satiety and rumino-reticular hypomotility in sheep.
MedLine Citation:
PMID:  6298549     Owner:  NLM     Status:  MEDLINE    
Continuous intracerebroventricular (ICV) infusion of CCK-octapeptide (CCK8) was performed in ewes fitted with a permanent cannula into the lateral cerebral ventricle and Nichrome electrodes on the reticulum in order to record its electrical activity. In the first series of experiments, subsequently repeated in 12 h fasted animals, CCK8 was infused during the first hour of a 3 hour period of feeding at 2.5, 5 and 10 The same series of infusion were performed 20 min after ICV injection of 2.4 and 10 of naloxone. CCK8 reduced significantly in a dose related manner the food intake (r = 0.95; P less than 0.01) and the frequency of cyclic spike bursts associated to biphasic contractions of the reticulum observed during feeding (r = 0.89; P less than 0.01). At 5 and 10, the reduction of food intake reached 46.2 and 52.6% during the period of infusion; the basal and stimulated (feeding) frequency of reticular contractions were nearly halved. Previous ICV administration of naloxone (2.4 partially blocked the effects of CCK8 infusion on both food intake (72%) and reticular frequency (54% basal, 67% stimulated). The CCK8 induced effects on both food intake and frequency of reticular contraction were completely abolished after a previous 10 injection of naloxone. These results suggest that the central effects of CCK8 on feeding behavior and forestomach motility involve similar central structures and are mediated through opiate receptor structures.
L Buéno; A Duranton; Y Ruckebusch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  32     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  855-63     Citation Subset:  IM    
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MeSH Terms
Appetite Depressants / administration & dosage,  antagonists & inhibitors*
Cholecystokinin / administration & dosage,  antagonists & inhibitors*
Dose-Response Relationship, Drug
Gastrointestinal Motility / drug effects*
Injections, Intraventricular
Muscle Contraction / drug effects
Naloxone / administration & dosage,  pharmacology*
Peptide Fragments / administration & dosage,  antagonists & inhibitors*
Reticulum / physiology*
Satiation / drug effects*
Satiety Response / drug effects*
Reg. No./Substance:
0/Appetite Depressants; 0/Peptide Fragments; 25126-32-3/Sincalide; 465-65-6/Naloxone; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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