Document Detail


Antagonistic effects of naloxone on CCK-octapeptide induced satiety and rumino-reticular hypomotility in sheep.
MedLine Citation:
PMID:  6298549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Continuous intracerebroventricular (ICV) infusion of CCK-octapeptide (CCK8) was performed in ewes fitted with a permanent cannula into the lateral cerebral ventricle and Nichrome electrodes on the reticulum in order to record its electrical activity. In the first series of experiments, subsequently repeated in 12 h fasted animals, CCK8 was infused during the first hour of a 3 hour period of feeding at 2.5, 5 and 10 ng.kg-1.min-1. The same series of infusion were performed 20 min after ICV injection of 2.4 and 10 micrograms.kg-1 of naloxone. CCK8 reduced significantly in a dose related manner the food intake (r = 0.95; P less than 0.01) and the frequency of cyclic spike bursts associated to biphasic contractions of the reticulum observed during feeding (r = 0.89; P less than 0.01). At 5 and 10 ng.kg-1.min-1, the reduction of food intake reached 46.2 and 52.6% during the period of infusion; the basal and stimulated (feeding) frequency of reticular contractions were nearly halved. Previous ICV administration of naloxone (2.4 micrograms.kg-1) partially blocked the effects of CCK8 infusion on both food intake (72%) and reticular frequency (54% basal, 67% stimulated). The CCK8 induced effects on both food intake and frequency of reticular contraction were completely abolished after a previous 10 micrograms.kg-1 injection of naloxone. These results suggest that the central effects of CCK8 on feeding behavior and forestomach motility involve similar central structures and are mediated through opiate receptor structures.
Authors:
L Buéno; A Duranton; Y Ruckebusch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  32     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  855-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants / administration & dosage,  antagonists & inhibitors*
Cholecystokinin / administration & dosage,  antagonists & inhibitors*
Dose-Response Relationship, Drug
Female
Gastrointestinal Motility / drug effects*
Injections, Intraventricular
Muscle Contraction / drug effects
Naloxone / administration & dosage,  pharmacology*
Peptide Fragments / administration & dosage,  antagonists & inhibitors*
Reticulum / physiology*
Satiation / drug effects*
Satiety Response / drug effects*
Sheep
Sincalide
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Peptide Fragments; 25126-32-3/Sincalide; 465-65-6/Naloxone; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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