| Antagonistic effects of naloxone on CCK-octapeptide induced satiety and rumino-reticular hypomotility in sheep. | |
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MedLine Citation:
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PMID: 6298549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Continuous intracerebroventricular (ICV) infusion of CCK-octapeptide (CCK8) was performed in ewes fitted with a permanent cannula into the lateral cerebral ventricle and Nichrome electrodes on the reticulum in order to record its electrical activity. In the first series of experiments, subsequently repeated in 12 h fasted animals, CCK8 was infused during the first hour of a 3 hour period of feeding at 2.5, 5 and 10 ng.kg-1.min-1. The same series of infusion were performed 20 min after ICV injection of 2.4 and 10 micrograms.kg-1 of naloxone. CCK8 reduced significantly in a dose related manner the food intake (r = 0.95; P less than 0.01) and the frequency of cyclic spike bursts associated to biphasic contractions of the reticulum observed during feeding (r = 0.89; P less than 0.01). At 5 and 10 ng.kg-1.min-1, the reduction of food intake reached 46.2 and 52.6% during the period of infusion; the basal and stimulated (feeding) frequency of reticular contractions were nearly halved. Previous ICV administration of naloxone (2.4 micrograms.kg-1) partially blocked the effects of CCK8 infusion on both food intake (72%) and reticular frequency (54% basal, 67% stimulated). The CCK8 induced effects on both food intake and frequency of reticular contraction were completely abolished after a previous 10 micrograms.kg-1 injection of naloxone. These results suggest that the central effects of CCK8 on feeding behavior and forestomach motility involve similar central structures and are mediated through opiate receptor structures. |
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Authors:
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L Buéno; A Duranton; Y Ruckebusch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 32 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1983 Feb |
Date Detail:
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Created Date: 1983-04-15 Completed Date: 1983-04-15 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 855-63 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Appetite Depressants / administration & dosage, antagonists & inhibitors* Cholecystokinin / administration & dosage, antagonists & inhibitors* Dose-Response Relationship, Drug Female Gastrointestinal Motility / drug effects* Injections, Intraventricular Muscle Contraction / drug effects Naloxone / administration & dosage, pharmacology* Peptide Fragments / administration & dosage, antagonists & inhibitors* Reticulum / physiology* Satiation / drug effects* Satiety Response / drug effects* Sheep Sincalide |
| Chemical | |
Reg. No./Substance:
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0/Appetite Depressants; 0/Peptide Fragments; 25126-32-3/Sincalide; 465-65-6/Naloxone; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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