Document Detail


Antagonistic effect of naloxone on the hypertensive response of intraventricularly administered histamine.
MedLine Citation:
PMID:  2142565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intracerebroventricular (i.c.v.) injections of histamine (HA) to Vetbutal-anaesthetized rats elicited a biphasic pressure response: a fall of blood pressure (BP) in the first minute, followed by a rise in BP. The heart rate (HR) response was also biphasic: bradycardia in the first minute, followed by tachycardia. The H1-receptor agonist 2-pyridylethylamine (PEA) increased the fall in BP in the first minute in comparison with the HA group, and then elicited a rise in BP that was, however, much lower than that produced by HA. Throughout the experiment PEA produced essentially only a bradycardia. The H2-receptor agonist dimaprit elicited a single-phase pressor response, i.e. a rise in BP and did not elicit tachycardia. Intraventricular pretreatment of rats with naloxone greatly reduced the initial response (phase 1) in the first minute in HA groups by 77-83% and PEA groups by 83-100%. Naloxone given in small doses also reduced the fall in HR by 71-100% in those groups. The experimental results permit a conclusion that the phase 1 response, i.e. the fall in BP, results from excitation of H1-receptors. Thus we may propose that H1-receptors are involved in the action of naloxone. Naloxone in a dose of 0.1 microgram inhibited the hypertensive responses of HA after 25-30 min. The reduction reached 71%. Naloxone reduced the small rise in BP induced by PEA (10 micrograms) but totally blocked the rise in BP induced by dimaprit (50 micrograms). This blockade indicates that the central opioid system may transmit the total stimulating response (rise in BP) of H2 receptors induced by dimaprit. Participation of central opioid receptors in HA-stimulated responses has already been demonstrated in corticosterone secretion.
Authors:
M S Młynarska
Related Documents :
20520575 - Prognostic value of isolated nocturnal hypertension on ambulatory measurement in 8711 i...
16006215 - Blood pressure profiles among makerere university undergraduate students.
25222695 - Parity and hypertension.
16915035 - Impaired blood pressure increase in acute cardioembolic stroke.
8884415 - Effect of strength training on blood pressure measured in various conditions in sedenta...
6877565 - Hydraulic model of the cerebrovascular bed: an aid to understanding the volume-pressure...
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Agents and actions     Volume:  30     ISSN:  0065-4299     ISO Abbreviation:  Agents Actions     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-08-17     Completed Date:  1990-08-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0213341     Medline TA:  Agents Actions     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  226-30     Citation Subset:  IM    
Affiliation:
Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Cimetidine / pharmacology
Dimaprit
Hemodynamics / drug effects
Histamine / administration & dosage,  pharmacology*
Injections, Intraventricular
Male
Naloxone / pharmacology*
Pyridines / pharmacology
Pyrilamine / pharmacology
Rats
Rats, Inbred Strains
Thiourea / pharmacology
Chemical
Reg. No./Substance:
0/Pyridines; 2706-56-1/2-(2-aminoethyl)pyridine; 465-65-6/Naloxone; 51-45-6/Histamine; 51481-61-9/Cimetidine; 62-56-6/Thiourea; 65119-89-3/Dimaprit; 91-84-9/Pyrilamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A selective role for brain histamine in prolactin release induced by opiates.
Next Document:  Beta-endorphin modulates anaphylactic contractions of tracheae isolated from actively sensitized gui...