Document Detail

Antagonistic action of prednisolone and buformin in the carbohydrate metabolism of healthy persons (author's transl)
MedLine Citation:
PMID:  815773     Owner:  NLM     Status:  MEDLINE    
Intravenous glucose tolerance tests were performed and changes of blood glucose and insulin concentration were measured to examine whether the diabetogenic effect of glucocorticoides can be compensated by biguanides. Seven standard weight volunteers with a healthy metabolism were given prednisolone and buformin as well as a combination of both. In spite of the reactively higher insulin secretion after treatment with prednisolone the glucose tolerance was reduced. In contrast, treatment with biguanide improved the glucose tolerance while decreasing the insulin secretion. It was nearly possible to compensate the negative effect of prednisolone on the carbohydrate metabolism by biguanides. We, therefore, consider a preventive administration of biguanides to be effective in long term or high dosage administration of glucocorticoides.
P Bottermann; U Schweigart; R Ermler
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Medizinische Klinik     Volume:  71     ISSN:  0025-8458     ISO Abbreviation:  Med Klin     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-05-20     Completed Date:  1976-05-20     Revised Date:  2007-08-13    
Medline Journal Info:
Nlm Unique ID:  0376637     Medline TA:  Med Klin     Country:  GERMANY, WEST    
Other Details:
Languages:  ger     Pagination:  275-80     Citation Subset:  IM    
Vernacular Title:
Funktioneller Antagonismus von Prednisolon und Buformin auf den Kohlenhydratstoffwechsel gesunder Personen
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MeSH Terms
Biguanides / pharmacology*
Buformin / pharmacology*
Carbohydrate Metabolism*
Diabetes Mellitus / prevention & control
Drug Combinations
Glucose / administration & dosage
Glucose Tolerance Test
Injections, Intravenous
Insulin / secretion
Long-Term Care
Prednisolone / adverse effects,  pharmacology*
Reg. No./Substance:
0/Biguanides; 0/Drug Combinations; 11061-68-0/Insulin; 50-24-8/Prednisolone; 50-99-7/Glucose; 692-13-7/Buformin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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