| Antagonistic action of prednisolone and buformin in the carbohydrate metabolism of healthy persons (author's transl) | |
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MedLine Citation:
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PMID: 815773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intravenous glucose tolerance tests were performed and changes of blood glucose and insulin concentration were measured to examine whether the diabetogenic effect of glucocorticoides can be compensated by biguanides. Seven standard weight volunteers with a healthy metabolism were given prednisolone and buformin as well as a combination of both. In spite of the reactively higher insulin secretion after treatment with prednisolone the glucose tolerance was reduced. In contrast, treatment with biguanide improved the glucose tolerance while decreasing the insulin secretion. It was nearly possible to compensate the negative effect of prednisolone on the carbohydrate metabolism by biguanides. We, therefore, consider a preventive administration of biguanides to be effective in long term or high dosage administration of glucocorticoides. |
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Authors:
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P Bottermann; U Schweigart; R Ermler |
Publication Detail:
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Type: English Abstract; Journal Article |
Journal Detail:
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Title: Medizinische Klinik Volume: 71 ISSN: 0025-8458 ISO Abbreviation: Med Klin Publication Date: 1976 Feb |
Date Detail:
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Created Date: 1976-05-20 Completed Date: 1976-05-20 Revised Date: 2007-08-13 |
Medline Journal Info:
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Nlm Unique ID: 0376637 Medline TA: Med Klin Country: GERMANY, WEST |
Other Details:
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Languages: ger Pagination: 275-80 Citation Subset: IM |
Vernacular Title:
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Funktioneller Antagonismus von Prednisolon und Buformin auf den Kohlenhydratstoffwechsel gesunder Personen |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biguanides
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pharmacology* Buformin / pharmacology* Carbohydrate Metabolism* Diabetes Mellitus / prevention & control Drug Combinations Glucose / administration & dosage Glucose Tolerance Test Humans Injections, Intravenous Insulin / secretion Long-Term Care Prednisolone / adverse effects, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Biguanides; 0/Drug Combinations; 11061-68-0/Insulin; 50-24-8/Prednisolone; 50-99-7/Glucose; 692-13-7/Buformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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