Document Detail


Antagonistic T-cell subsets in skin diseases.
MedLine Citation:
PMID:  21995403     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
To the Editor: Eyerich et al. (July 21 issue)(1) evaluate patients presenting with both psoriasis and atopic eczema, and they conclude, on the basis of their distinct cytokine profiles and reactivity to nickel, that T cells infiltrating these different lesions target different antigens. However, they did not investigate at the clonal level either the T-cell receptor clonal signatures involved or their formal peptide-antigen specificity. "Fate-mapping" studies (to determine the cellular derivatives of a cell or population of cells) show that T cells are intrinsically unstable both in vitro and in vivo.(2),(3) We recently analyzed both cytokine profiles and T-cell-receptor . . .
Authors:
Francesco Borriello; Raffaele De Palma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  365     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1450-2     Citation Subset:  AIM; IM    
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