Document Detail


Antagonism of the hypermotility response induced by excitatory amino acids in the rat nucleus accumbens.
MedLine Citation:
PMID:  6369149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several compounds have been shown to antagonize the excitation of single neurons produced by excitatory amino acids. This study was designed to determine the effectiveness of these compounds in antagonizing the hypermotility response to excitatory amino acids after intra-accumbens administration. Of the putative antagonists tested, D-aminoadipic acid, diaminopimelic acid and glutamic acid diethyl ester all showed significant inhibitory effects on excitatory amino acid-induced hypermotility while 2-amino-5-phosphonovaleric acid, gamma-D-glutamylglycine, 2-amino-4-phosphonobutyric acid and cis-2,3-piperidine dicarboxylic acid were ineffective. D-Aminoadipic acid decreased N-methyl-aspartic acid-induced hypermotility while having no significant effect on the hypermotility responses induced by kainic or quisqualic acids. Diaminopimelic acid markedly decreased N-methyl-aspartic acid- and kainic acid-induced hypermotility but was totally ineffective on quisqualic acid-induced hypermotility. In contrast to D-aminoadipic acid, glutamic acid diethyl ester antagonized the increase in motility produced by kainic and quisqualic acids but not that produced by N-methyl-aspartic acid. The above data suggests that N-methyl-aspartic acid and quisqualic acid may produce their motor effects through the activation of two different receptors in the nucleus accumbens while kainic acid may mediate its hypermotility response through both N-methyl-aspartic acid and quisqualic acid receptors. However, a third receptor type activated solely by kainic acid cannot be excluded at this time.
Authors:
B A Donzanti; N J Uretsky
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  325     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-05-11     Completed Date:  1984-05-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
2-Aminoadipic Acid / pharmacology
Amino Acids / pharmacology*
Animals
Aspartic Acid / analogs & derivatives,  pharmacology
Diaminopimelic Acid / pharmacology
Glutamates / pharmacology
Injections
Kainic Acid / pharmacology
Male
Motor Activity / drug effects*
N-Methylaspartate
Nucleus Accumbens / drug effects*
Oxadiazoles / pharmacology
Quisqualic Acid
Rats
Rats, Inbred Strains
Septal Nuclei / drug effects*
Grant Support
ID/Acronym/Agency:
R01-NS-13888/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Glutamates; 0/Oxadiazoles; 16450-41-2/glutamic acid diethyl ester; 487-79-6/Kainic Acid; 52809-07-1/Quisqualic Acid; 542-32-5/2-Aminoadipic Acid; 56-84-8/Aspartic Acid; 583-93-7/Diaminopimelic Acid; 6384-92-5/N-Methylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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