Document Detail

Antagonism of diazepam sedation by flumazenil.
MedLine Citation:
PMID:  2513859     Owner:  NLM     Status:  MEDLINE    
Forty adult patients undergoing elective surgery, anaesthetized with diazepam, alfentanil and nitrous oxide in oxygen, and paralysed with atracurium were given flumazenil or placebo i.v. in a double-blind randomized study to assess the efficacy of flumazenil. Awake state, heart rate, arterial pressure, rate of ventilation and arterial blood-gas values were measured at 0, 5, 30, 120 and 240 min after administration of flumazenil or placebo. Flumazenil was found to antagonize the sedative effects of diazepam; there was no resedation within the time of observation. There were no intergroup differences in any of the other measured variables. A median dose of diazepam 0.33 mg kg-1 during surgery lasting a median of 98 min was antagonized by a median dose of flumazenil 0.35 mg. No side effects related to flumazenil were observed.
M Skielboe; P Andersen; M Weber; I L Jarnvig; B Jørgensen; C Christiansen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  63     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-02-13     Completed Date:  1990-02-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  554-7     Citation Subset:  IM    
Department of Anesthesiology, Hospital of Frederiksberg, Copenhagen, Denmark.
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MeSH Terms
Aged, 80 and over
Anesthesia, General
Carbon Dioxide / blood
Diazepam / antagonists & inhibitors*
Double-Blind Method
Flumazenil / administration & dosage,  pharmacology*
Middle Aged
Nitrous Oxide
Oxygen / blood
Randomized Controlled Trials as Topic
Wakefulness / drug effects
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 124-38-9/Carbon Dioxide; 439-14-5/Diazepam; 71195-58-9/Alfentanil; 7782-44-7/Oxygen; 78755-81-4/Flumazenil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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