| Antagonism of calcium-induced contraction in potassium-depolarized rabbit detrusor muscle strips by dicyclomine hydrochloride and rociverine. | |
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MedLine Citation:
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PMID: 7296384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The musculotropic action of dicyclomine hydrochloride in bladder muscle has been attributed to its local anesthetic activity. In this study rabbit detrusor strips were depleted of calcium by incubation in Ca2+-free solution containing ethylene glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid (EGTA). Contractions elicited by replacement of Ca2+ during depolarization with 80 mM K+ were only slightly affected by atropine or scopolamine but were antagonized in a noncompetitive manner by dicyclomine and rociverine (pD2' = 4.89 and 4.61, respectively). These contractions were also blocked with greater potency by nifedipine (pD2' = 8.50) and with lesser potency by lidocaine (pD2' = 2.52). Procaine was ineffective up to 1 mM. Comparison of the antagonism produced by dicyclomine and rociverine with that produced by nifedipine or lidocaine did not help to define the mechanism of the musculotropic drugs. However, as rociverine is not a local anesthetic and procaine was not effective, it appears that the "local anesthetic" property is not sufficient to explain the action of these musculotropic drugs. |
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Authors:
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J W Downie; R P McGuire |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 59 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1981 Aug |
Date Detail:
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Created Date: 1982-01-09 Completed Date: 1982-01-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
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Languages: eng Pagination: 853-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology Bicyclo Compounds / pharmacology* Bridged Compounds / pharmacology* Calcium Channel Blockers* Cyclohexanecarboxylic Acids / pharmacology* Dicyclomine / pharmacology* Lidocaine / pharmacology Male Muscle Contraction / drug effects* Muscle, Smooth / drug effects* Potassium / pharmacology Rabbits Urinary Bladder / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Bicyclo Compounds; 0/Bridged Compounds; 0/Calcium Channel Blockers; 0/Cyclohexanecarboxylic Acids; 137-58-6/Lidocaine; 51-55-8/Atropine; 53716-44-2/rociverine; 7440-09-7/Potassium; 77-19-0/Dicyclomine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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