Document Detail

Antacids and dietary supplements with an influence on the gastric pH increase the risk for food sensitization.
MedLine Citation:
PMID:  20214670     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Elevation of the gastric pH increases the risk for sensitization against food allergens by hindering protein breakdown. This can be caused by acid-suppressing medication like sucralphate, H2-receptor blockers and proton pump inhibitors, as shown in recent murine experimental and human observational studies.
OBJECTIVE: The aim of the present study was to assess the sensitization capacity of the dietary supplement base powder and of over-the-counter antacids.
METHODS: Changes of the pH as well as of protein digestion due to base powder or antacids were measured in vitro. To examine the in vivo influence, BALB/c mice were fed codfish extract with one of the acid-suppressing substances. Read-out of antibody levels in the sera, of cytokine levels of stimulated splenocytes and of intradermal skin tests was performed.
RESULTS: The pH of hydrochloric acid was substantially increased in vitro by base powder as well as antacids in a time- and dose-dependent manner. This elevation hindered the digestion of codfish proteins in vitro. A significant increase in codfish-specific IgE antibodies was found in the groups fed codfish combined with Rennie Antacidum or with base powder; the latter also showed significantly elevated IgG1 and IgG2a levels. The induction of an anaphylactic immune response was proven by positive results in intradermal skin tests.
CONCLUSIONS: Antacids and dietary supplements influencing the gastric pH increase the risk for sensitization against allergenic food proteins. As these substances are commonly used in the general population without consulting a physician, our data may have a major practical and clinical impact.
I Pali-Schöll; R Herzog; J Wallmann; K Szalai; R Brunner; A Lukschal; P Karagiannis; S C Diesner; E Jensen-Jarolim
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-04
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  40     ISSN:  1365-2222     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-11-16     Revised Date:  2014-02-12    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  1091-8     Citation Subset:  IM    
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MeSH Terms
Allergens / immunology
Antacids / adverse effects*
Dietary Supplements / adverse effects*
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Fish Proteins / immunology
Food Hypersensitivity / complications*,  immunology*
Hydrogen-Ion Concentration
Nonprescription Drugs / adverse effects
Stomach Ulcer / complications
Grant Support
F 1808-B13//Austrian Science Fund FWF; T 283-B13//Austrian Science Fund FWF
Reg. No./Substance:
0/Allergens; 0/Antacids; 0/Fish Proteins; 0/Nonprescription Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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