| Antacids and dietary supplements with an influence on the gastric pH increase the risk for food sensitization. | |
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MedLine Citation:
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PMID: 20214670 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Elevation of the gastric pH increases the risk for sensitization against food allergens by hindering protein breakdown. This can be caused by acid-suppressing medication like sucralphate, H2-receptor blockers and proton pump inhibitors, as shown in recent murine experimental and human observational studies. OBJECTIVE: The aim of the present study was to assess the sensitization capacity of the dietary supplement base powder and of over-the-counter antacids. METHODS: Changes of the pH as well as of protein digestion due to base powder or antacids were measured in vitro. To examine the in vivo influence, BALB/c mice were fed codfish extract with one of the acid-suppressing substances. Read-out of antibody levels in the sera, of cytokine levels of stimulated splenocytes and of intradermal skin tests was performed. RESULTS: The pH of hydrochloric acid was substantially increased in vitro by base powder as well as antacids in a time- and dose-dependent manner. This elevation hindered the digestion of codfish proteins in vitro. A significant increase in codfish-specific IgE antibodies was found in the groups fed codfish combined with Rennie Antacidum or with base powder; the latter also showed significantly elevated IgG1 and IgG2a levels. The induction of an anaphylactic immune response was proven by positive results in intradermal skin tests. CONCLUSIONS: Antacids and dietary supplements influencing the gastric pH increase the risk for sensitization against allergenic food proteins. As these substances are commonly used in the general population without consulting a physician, our data may have a major practical and clinical impact. |
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Authors:
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I Pali-Schöll; R Herzog; J Wallmann; K Szalai; R Brunner; A Lukschal; P Karagiannis; S C Diesner; E Jensen-Jarolim |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-04 |
Journal Detail:
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Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 40 ISSN: 1365-2222 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-11-16 Revised Date: 2013-02-22 |
Medline Journal Info:
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Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
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Languages: eng Pagination: 1091-8 Citation Subset: IM |
Affiliation:
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IPP-Department of Pathophysiology, Centre of Physiology, Pathophysiology and Immunology, Medical University of Vienna, Vienna, Austria. isabella.pali@meduniwien.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Allergens
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immunology Animals Antacids / adverse effects* Dietary Supplements / adverse effects* Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Female Fish Proteins / immunology Food Hypersensitivity / complications*, immunology* Humans Hydrogen-Ion Concentration Mice Nonprescription Drugs / adverse effects Stomach Ulcer / complications |
| Grant Support | |
ID/Acronym/Agency:
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F 1808-B13//Austrian Science Fund FWF |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Antacids; 0/Fish Proteins; 0/Nonprescription Drugs |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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