Document Detail

Antacid therapy and nutritional supplementation in the prevention of Curling's ulcer.
MedLine Citation:
PMID:  369008     Owner:  NLM     Status:  MEDLINE    
The incidence of clinically evident Curling's ulcer among 109 potentially salvageable severely burned patients was reviewed. These patients, who had greater than a 40 per cent body surface area burn, received one of these three treatment regimens: antacids hourly until autografting was complete, antacids hourly during the early postburn period followed by nutritional supplementation with Vivonex until autografting was complete or no antacids during the early postburn period but subsequent nutritional supplementation with Vivonex until autografting was complete. Clinically evident Curling's ulcer occurred in three patients. This incidence approximates the lowest reported among severely burned patients treated prophylactically with acid-reducing regimens to minimize clinically evident Curling's ulcer. In addition to its protective effect on Curling's ulcer, Vivonex, when used in combination with a high protein, high caloric diet, meets the caloric needs of the severely burned patient. Probably, Vivonex, which has a pH range of 4.5 to 5.4 protects against clinically evident Curling's ulcer by a dilutional alkalinization of gastric secretion.
L D Solem; R G Strate; R P Fischer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  148     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-04-28     Completed Date:  1979-04-28     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  367-70     Citation Subset:  AIM; IM    
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MeSH Terms
Antacids / therapeutic use*
Burns / complications*,  diet therapy,  drug therapy
Food, Formulated*
Gastrointestinal Hemorrhage / complications
Middle Aged
Peptic Ulcer / diet therapy,  drug therapy,  prevention & control*
Skin Transplantation
Transplantation, Autologous
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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