Document Detail


The Anrep effect: an intrinsic myocardial mechanism.
MedLine Citation:
PMID:  3214805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In cat papillary muscles contracting physiologically, increasing the afterload caused a biphasic change in contractility. In response to an increase in afterload, contractility (as measured by peak shortening, peak developed force, or peak dF/dt) initially decreased (antihomeometric autoregulation) over the first few beats and then increased slowly with t 1/2 of about 3 min at 30 degrees C and about 1 min at 37 degrees C (homeometric autoregulation). The antihomeometric autoregulation is due to decreased active shortening when the afterload is increased, since it also occurs in response to increased afterload in isotonic contractions. The secondary slow increase in contractility is primarily due to the increase in mean diastolic length that occurs as a result of increased afterload. The time course and the magnitude of the biphasic change in contractility are very similar to those observed in response to afterload increase in intact hearts; we suggest that the secondary slow increase in contractility that we observed is a contributory mechanism to homeometric autoregulation (or the Anrep effect), as it is observed in the whole heart.
Authors:
C G Nichols; D A Hanck; B R Jewell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  66     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1989-03-07     Completed Date:  1989-03-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  924-9     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Leeds, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats
Heart / physiology*
Homeostasis
Isometric Contraction
Myocardial Contraction*
Papillary Muscles / physiology
Grant Support
ID/Acronym/Agency:
IF32-HL-06251-01/HL/NHLBI NIH HHS
Comments/Corrections
Erratum In:
Can J Physiol Pharmacol 1989 Feb;67(2):172

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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