Document Detail


Anorexigenic effects of central neuropeptide S involve the hypothalamus in chicks (Gallus gallus).
MedLine Citation:
PMID:  17884648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuropeptide S (NPS) affects appetite-related processes in mammals. However, its role in avian biology is unreported. We hypothesized that intracerebroventricular (ICV) NPS would cause anorexigenic effects in chicks (Gallus gallus). To evaluate this, Cobb-500 chicks were centrally injected with multiple doses (0, 0.313, 0.625 and 1.250 mug) of NPS. NPS-treated chicks responded with decreased feed and water intake. The effect on water intake was secondary to feed intake, because fasted NPS-treated chicks did not reduce water intake. ICV NPS injection also reduced plasma corticosterone concentration. We monitored behavior and found decreased ingestive and exploratory pecking, jumping, locomotion, and increased time spent in deep rest. We hypothesized that the anorexigenic effects were hypothalamic in origin and quantified c-Fos reactivity in the lateral hypothalamus (LH), paraventricular nucleus (PVN) and ventromedial hypothalamus (VMH) after NPS treatment. NPS was associated with decreased c-Fos reactivity in the LH, increased reactivity in the PVN and had no effect in the VMH. When NPS was injected directly into the LH and PVN, chicks responded with decreased feed and water intake, suggesting that effects were directly mediated by these nuclei. We conclude that ICV NPS causes anorexigenic effects in chicks, without directly affecting water intake, and the hypothalamus is involved.
Authors:
Mark A Cline; David C Godlove; Wint Nandar; Christie N Bowden; Brian C Prall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-21
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  148     ISSN:  1095-6433     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-02     Completed Date:  2007-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  657-63     Citation Subset:  IM    
Affiliation:
Department of Biology P.O. Box 6931, Radford University, Radford, Virginia 24142, USA. mcline@radford.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Appetite Depressants / administration & dosage,  metabolism*
Appetite Regulation* / drug effects
Behavior, Animal
Chickens
Corticosterone / blood
Dose-Response Relationship, Drug
Drinking
Eating
Hypothalamic Area, Lateral / metabolism
Hypothalamus / drug effects,  metabolism*
Immunohistochemistry
Injections, Intraventricular
Neuropeptides / administration & dosage,  metabolism*
Paraventricular Hypothalamic Nucleus / metabolism
Proto-Oncogene Proteins c-fos / metabolism
Ventromedial Hypothalamic Nucleus / metabolism
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Neuropeptides; 0/Proto-Oncogene Proteins c-fos; 50-22-6/Corticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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