Document Detail


Anorexigenic effects of GLP-1 and its analogues.
MedLine Citation:
PMID:  22249815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
GLP-1 receptors are expressed in the brain, especially in the regions responsible for the regulation of food intake, and intracerebroventricular injection of GLP-1 results in inhibition of food intake. Peripheral administration of GLP-1 dose-dependently enhances satiety and reduces food intake in normal and obese subjects as well as in type 2 diabetic patients. So far, the mechanisms by which GLP-1 exerts its effects are not completely clear. Interactions with neurons in the gastrointestinal tract or possibly direct access to the brain through the blood-brain barrier as observed in rats are possible and discussed in this chapter as well as a novel hypothesis based on the finding that GLP-1 is also expressed in taste cells. Finally, the role of GLP-1 receptor agonists as a possible treatment option in obesity is discussed as well as the role of GLP-1 in the effects of bariatric surgery on adiposity and glucose homeostasis.
Authors:
Baptist Gallwitz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Handbook of experimental pharmacology     Volume:  -     ISSN:  0171-2004     ISO Abbreviation:  Handb Exp Pharmacol     Publication Date:  2012  
Date Detail:
Created Date:  2012-01-17     Completed Date:  2012-04-25     Revised Date:  2013-03-19    
Medline Journal Info:
Nlm Unique ID:  7902231     Medline TA:  Handb Exp Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  185-207     Citation Subset:  IM    
Affiliation:
Medizinische Klinik IV, Otfried-Müller-Str. 10, 72076 Tübingen, Germany. baptist.gallwitz@med.uni-tuebingen.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants / pharmacology*
Appetite Regulation / drug effects
Bariatric Surgery
Body Weight / drug effects
Brain / drug effects*,  metabolism
Eating / drug effects
Glucagon-Like Peptide 1 / analogs & derivatives,  metabolism,  pharmacology*
Humans
Incretins / pharmacology*
Obesity / drug therapy,  metabolism,  surgery
Receptors, Glucagon / agonists*,  metabolism
Satiety Response / drug effects
Signal Transduction / drug effects
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Incretins; 0/Receptors, Glucagon; 0/glucagon-like peptide-1 receptor; 89750-14-1/Glucagon-Like Peptide 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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