| Anorexia nervosa depends on adrenal sympathetic hyperactivity: opposite neuroautonomic profile of hyperinsulinism syndrome. | |
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MedLine Citation:
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PMID: 21437100 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of our study was to determine the central and peripheral autonomic nervous system profiles underlying anorexia nervosa (AN) syndrome, given that affected patients present with the opposite clinical profile to that seen in the hyperinsulinism syndrome. DESIGN: We measured blood pressure and heart rate, as well as circulating neurotransmitters (noradrenaline, adrenaline, dopamine, plasma serotonin, and platelet serotonin), using high-performance liquid chromatography with electrochemical detection, during supine resting, one minute of orthostasis, and after five minutes of exercise. In total, 22 AN patients (12 binge-eating/purging type and 10 restricting type) and age-, gender-, and race-matched controls (70 ± 10.1% versus 98 ± 3.0% of ideal body weight) were recruited. RESULTS: We found that patients with AN had adrenal sympathetic overactivity and neural sympathetic underactivity, demonstrated by a predominance of circulating adrenaline over noradrenaline levels, not only during the supine resting state (52 ± 2 versus 29 ± 1 pg/mL) but also during orthostasis (67 ± 3 versus 32 ± 2 pg/mL, P < 0.05) and after exercise challenge (84 ± 4 versus 30 ± 3 pg/mL, P < 0.01). CONCLUSION: Considering that this peripheral autonomic nervous system disorder depends on the absolute predominance of adrenomedullary C1 adrenergic nuclei over A5 noradrenergic pontine nucleus, let us ratify the abovementioned findings. The AN syndrome depends on the predominance of overwhelming adrenal sympathetic activity over neural sympathetic activity. This combined central and autonomic nervous system profile contrasts with that registered in patients affected by hyperinsulinism, hypoglycemia, and bulimia syndrome which depends on the absolute predominance of neural sympathetic activity. |
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Authors:
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Fuad Lechin; Bertha van der Dijs; Betty Pardey-Maldonado; Jairo E Rivera; Scarlet Baez; Marcel E Lechin |
Publication Detail:
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Type: Journal Article Date: 2010-09-09 |
Journal Detail:
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Title: Diabetes, metabolic syndrome and obesity : targets and therapy Volume: 3 ISSN: 1178-7007 ISO Abbreviation: Diabetes Metab Syndr Obes Publication Date: 2010 |
Date Detail:
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Created Date: 2011-03-25 Completed Date: 2011-07-14 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 101515585 Medline TA: Diabetes Metab Syndr Obes Country: New Zealand |
Other Details:
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Languages: eng Pagination: 311-7 Citation Subset: - |
Affiliation:
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Department of Pathophysiology, Sections of Neuroendocrinology, Neuropharmacology, and Neurochemistry, Instituto de Medicina Experimental, Faculty of Medicine, Universidad Central de Venezuela, Caracas. |
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