Document Detail

Anorectic specificity as measured in a choice paradigm in rhesus monkeys.
MedLine Citation:
PMID:  8516352     Owner:  NLM     Status:  MEDLINE    
The present report describes a new procedure for assessing anorectic specificity. Two rhesus monkeys (Macaca mulatta) surgically prepared with indwelling intragastric catheters were trained in a discrete trial choice paradigm to respond for either food or visual access to a room containing other monkeys. Our hypothesis was that a specific anorectic would reduce only food-maintained responding; responding to open a window would either not be affected or would increase. Caloric preloads, d-amphetamine, (d,l)-fenfluramine, and cholecystokinin octapeptide all decreased food-maintained responding and had no effect on or increased responding maintained by window opening. These results demonstrate that choice procedures are useful for assessing anorectic specificity.
R L Corwin; C R Schuster
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  45     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-19     Completed Date:  1993-07-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  131-41     Citation Subset:  IM    
Department of Psychiatry, University of Chicago, IL 60637.
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MeSH Terms
Amphetamine / pharmacology
Appetite Depressants / pharmacology*
Choice Behavior / drug effects*
Cholecystokinin / pharmacology
Conditioning, Operant / drug effects
Eating / drug effects
Fenfluramine / pharmacology
Macaca mulatta
Self Administration
Grant Support
Reg. No./Substance:
0/Appetite Depressants; 300-62-9/Amphetamine; 458-24-2/Fenfluramine; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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