Document Detail

Anorectic responses to dietary amino acid imbalance: effects of vagotomy and tropisetron.
MedLine Citation:
PMID:  8024048     Owner:  NLM     Status:  MEDLINE    
We investigated the roles of the vagus nerve and the serotonin3 (5-HT3) receptor in mediating the food intake depression associated with amino acid deficiency. The food intake of sham-operated (sham) rats given an isoleucine-imbalanced (IMB) diet was reduced to < 40% of control basal (BAS) diet intake (P = 0.0009), and pretreatment with the 5-HT3 antagonist tropisetron (Trop) increased IMB intake by twofold over the vehicle (VEH)-treated group (P < or = 0.0001), as we have reported before. However, after subdiaphragmatic vagotomy (VAGX), IMB intake was increased to a level intermediate between the sham-VEH and sham-Trop groups, while administration of Trop did not increase IMB intake over VAGX alone. By the end of day 1, the VAGX-Trop group had eaten only 1 g more of IMB than the VAGX-VEH group (NS). We conclude that 1) the vagus is among the physiological systems involved in the anorectic responses to IMB and 2) intact vagal function is necessary for the full effect of 5-HT3 antagonists in alleviating the anorectic responses to IMB.
B S Washburn; J C Jiang; S L Cummings; K Dixon; D W Gietzen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  266     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-08-02     Completed Date:  1994-08-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1922-7     Citation Subset:  IM    
Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
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MeSH Terms
Anorexia Nervosa / etiology*,  physiopathology
Eating / drug effects
Indoles / pharmacology*
Isoleucine / administration & dosage,  deficiency*
Rats, Sprague-Dawley
Serotonin Antagonists / pharmacology
Grant Support
Reg. No./Substance:
0/Indoles; 0/Serotonin Antagonists; 73-32-5/Isoleucine; 89565-68-4/tropisetron

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